Expression of KCNK17 in cancer - Summary - The Human Protein Atlas

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KCNK17

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KCNK17
Gene description	Potassium channel, two pore domain subfamily K, member 17
Protein class	Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (SCLC-21H)
HPA (normal tissue):	Tissue enhanced (lung)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA043892
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043892

GENE INFORMATION
Gene name	KCNK17 (HGNC Symbol)
Synonyms	K2p17.1, TALK-2, TALK2, TASK-4, TASK4
Description	Potassium channel, two pore domain subfamily K, member 17 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Chromosome	6
Cytoband	p21.2
Chromosome location (bp)	39299001 - 39314553
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000124780 (version 83.38)
Entrez gene	89822
UniProt	Q96T54 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96T54
Antibodypedia	KCNK17 antibodies

PROTEIN BROWSER

KCNK17-001	KCNK17-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNK17-001 ENSP00000362328 ENST00000373231	Q96T54 [Direct mapping] Potassium channel subfamily K member 17 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	332 aa 36.9 kDa	No	6
KCNK17-002 ENSP00000401271 ENST00000453413	Q96T54 [Direct mapping] Potassium channel subfamily K member 17 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	271 aa 30 kDa	No	5

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.