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RREB1

GENERAL INFORMATION

Gene name

 RREB1

Gene description

 Ras responsive element binding protein 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA001756
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001756

GENE INFORMATION

Gene name

 RREB1 (HGNC Symbol)

Synonyms

 HNT

Description

 Ras responsive element binding protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Chromosome

 6

Cytoband

 p24.3

Chromosome location (bp)

 7107597 - 7251980

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124782 (version 83.38)

Entrez gene

 6239

UniProt

 Q92766 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92766

Antibodypedia

 RREB1 antibodies

PROTEIN BROWSER
RREB1-001
RREB1-002
RREB1-003
RREB1-004
RREB1-007
RREB1-008
RREB1-011
RREB1-012
RREB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RREB1-001
ENSP00000369270
ENST00000379938
Q92766 [Direct mapping]
Ras-responsive element-binding protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0016604 [nuclear body]
GO:0016607 [nuclear speck]
GO:0033601 [positive regulation of mammary gland epithelial cell proliferation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903691 [positive regulation of wound healing, spreading of epidermal cells]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
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 1742 aa
187.6 kDa 		No 0
RREB1-002
ENSP00000305560
ENST00000349384
Q92766 [Direct mapping]
Ras-responsive element-binding protein 1
A0A024QZU8 [Target identity:100%; Query identity:100%]
Ras responsive element binding protein 1, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0016604 [nuclear body]
GO:0016607 [nuclear speck]
GO:0033601 [positive regulation of mammary gland epithelial cell proliferation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903691 [positive regulation of wound healing, spreading of epidermal cells]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 1687 aa
181.4 kDa 		No 0
RREB1-003
ENSP00000335574
ENST00000334984
Q92766 [Direct mapping]
Ras-responsive element-binding protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0016604 [nuclear body]
GO:0016607 [nuclear speck]
GO:0033601 [positive regulation of mammary gland epithelial cell proliferation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903691 [positive regulation of wound healing, spreading of epidermal cells]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 1476 aa
159.3 kDa 		No 0
RREB1-004
ENSP00000369265
ENST00000379933
Q92766 [Direct mapping]
Ras-responsive element-binding protein 1
A0A024QZU8 [Target identity:100%; Query identity:100%]
Ras responsive element binding protein 1, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0016604 [nuclear body]
GO:0016607 [nuclear speck]
GO:0033601 [positive regulation of mammary gland epithelial cell proliferation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903691 [positive regulation of wound healing, spreading of epidermal cells]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 1687 aa
181.4 kDa 		No 0
RREB1-007
ENSP00000420519
ENST00000491191
C9JE09 [Direct mapping]
Ras-responsive element-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
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 136 aa
14.5 kDa 		No 0
RREB1-008
ENSP00000419511
ENST00000483150
C9JU34 [Direct mapping]
Ras-responsive element-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 778 aa
85.5 kDa 		No 0
RREB1-011
ENSP00000420299
ENST00000471433
C9JPJ6 [Direct mapping]
Ras-responsive element-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 164 aa
17.6 kDa 		No 0
RREB1-012
ENSP00000420571
ENST00000467782
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 4 aa
0.4 kDa 		No 0
RREB1-201
ENSP00000483108
ENST00000611109
A0A087X055 [Direct mapping]
Ras-responsive element-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
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 755 aa
79.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.