Expression of SSR1 in cancer - Summary - The Human Protein Atlas

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SSR1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SSR1
Gene description	Signal sequence receptor, alpha
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA011276 , HPA017062
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011276	HPA017062

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Cancer cells showed weak to moderate cytoplasmic immunoreactivity. A few colorectal, pancreatic, gastric and liver cancers were strongly stained.

GENE INFORMATION
Gene name	SSR1 (HGNC Symbol)
Synonyms	TRAPA
Description	Signal sequence receptor, alpha (HGNC Symbol)
Entrez gene summary	The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Chromosome	6
Cytoband	p24.3
Chromosome location (bp)	7268306 - 7347446
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124783 (version 83.38)
Entrez gene	6745
UniProt	P43307 (UniProt - Evidence at protein level)
neXtProt	NX_P43307
Antibodypedia	SSR1 antibodies

PROTEIN BROWSER

SSR1-001	SSR1-002	SSR1-003	SSR1-006	SSR1-007	SSR1-010	SSR1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SSR1-001 ENSP00000244763 ENST00000244763	P43307 [Direct mapping] Translocon-associated protein subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006412 [translation] GO:0006613 [cotranslational protein targeting to membrane] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008284 [positive regulation of cell proliferation] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0044267 [cellular protein metabolic process] Show all	286 aa 32.2 kDa	Yes	1
SSR1-002 ENSP00000380647 ENST00000397511	E9PAL7 [Direct mapping] Translocon-associated protein subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	291 aa 32.9 kDa	Yes	1
SSR1-003 ENSP00000418617 ENST00000474597	C9IZQ1 [Direct mapping] Translocon-associated protein subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	298 aa 33.9 kDa	Yes	1
SSR1-006 ENSP00000420730 ENST00000489567	C9JBX5 [Direct mapping] Translocon-associated protein subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	218 aa 24.4 kDa	Yes	1
SSR1-007 ENSP00000417911 ENST00000479365	C9J5W0 [Direct mapping] Translocon-associated protein subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	266 aa 29.9 kDa	Yes	1
SSR1-010 ENSP00000419953 ENST00000479485	C9JY01 [Direct mapping] Translocon-associated protein subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	103 aa 11.6 kDa	No	1
SSR1-011 ENSP00000417290 ENST00000462112	C9J3L8 [Direct mapping] Translocon-associated protein subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	265 aa 29.6 kDa	Yes	1

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