Expression of DEK in cancer - Summary - The Human Protein Atlas

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DEK

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DEK
Gene description	DEK proto-oncogene
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA054505 , HPA057799 , CAB015226
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA054505	HPA057799	CAB015226

GENE INFORMATION
Gene name	DEK (HGNC Symbol)
Synonyms	D6S231E
Description	DEK proto-oncogene (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Chromosome	6
Cytoband	p22.3
Chromosome location (bp)	18223868 - 18264823
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124795 (version 83.38)
Entrez gene	7913
UniProt	P35659 (UniProt - Evidence at protein level)
neXtProt	NX_P35659
Antibodypedia	DEK antibodies

PROTEIN BROWSER

DEK-001	DEK-002	DEK-005	DEK-006	DEK-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEK-001 ENSP00000380414 ENST00000397239	P35659 [Direct mapping] Protein DEK Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0016568 [chromatin modification] GO:0019079 [viral genome replication] GO:0042393 [histone binding] GO:0043292 [contractile fiber] GO:0044822 [poly(A) RNA binding] GO:2000779 [regulation of double-strand break repair] GO:2001032 [regulation of double-strand break repair via nonhomologous end joining] Show all	375 aa 42.7 kDa	No	0
DEK-002 ENSP00000244776 ENST00000244776	P35659 [Direct mapping] Protein DEK Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0016568 [chromatin modification] GO:0019079 [viral genome replication] GO:0042393 [histone binding] GO:0044822 [poly(A) RNA binding] GO:2000779 [regulation of double-strand break repair] Show all	341 aa 38.7 kDa	No	0
DEK-005 ENSP00000425399 ENST00000503715	D6RDA2 [Direct mapping] Protein DEK Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		122 aa 14.2 kDa	No	0
DEK-006 ENSP00000423553 ENST00000515742	D6R9L5 [Direct mapping] Protein DEK Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		151 aa 17.3 kDa	No	0
DEK-009 ENSP00000423427 ENST00000507591	H0Y993 [Direct mapping] Protein DEK Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] Show all	156 aa 17.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.