Expression of OPN5 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

OPN5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OPN5
Gene description	Opsin 5
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in photoreceptor cells in retina and processes in brain.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Supported based on 1 antibody. HPA026084
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026084

GENE INFORMATION
Gene name	OPN5 (HGNC Symbol)
Synonyms	dJ402H5.1, neuropsin, TMEM13
Description	Opsin 5 (HGNC Symbol)
Entrez gene summary	Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Chromosome	6
Cytoband	p12.3
Chromosome location (bp)	47781982 - 47832780
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124818 (version 83.38)
Entrez gene	221391
UniProt	Q6U736 (UniProt - Evidence at protein level)
neXtProt	NX_Q6U736
Antibodypedia	OPN5 antibodies

PROTEIN BROWSER

OPN5-002	OPN5-003	OPN5-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OPN5-002 ENSP00000426991 ENST00000489301	D6RDV4 [Direct mapping] Opsin-5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007601 [visual perception] GO:0009881 [photoreceptor activity] GO:0016021 [integral component of membrane] GO:0018298 [protein-chromophore linkage] Show all	382 aa 42.7 kDa	No	6
OPN5-003 ENSP00000360255 ENST00000371211	Q6U736 [Direct mapping] Opsin-5 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Opsins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005502 [11-cis retinal binding] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007601 [visual perception] GO:0007602 [phototransduction] GO:0009881 [photoreceptor activity] GO:0016021 [integral component of membrane] GO:0018298 [protein-chromophore linkage] Show all	354 aa 39.7 kDa	No	7
OPN5-005 ENSP00000377302 ENST00000393699	J3KPQ2 [Direct mapping] Opsin 5; Opsin-5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007601 [visual perception] GO:0009881 [photoreceptor activity] GO:0016021 [integral component of membrane] GO:0018298 [protein-chromophore linkage] Show all	353 aa 39.5 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.