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LRRFIP1

GENERAL INFORMATION

Gene name

 LRRFIP1

Gene description

 Leucine rich repeat (in FLII) interacting protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA006979
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006979

GENE INFORMATION

Gene name

 LRRFIP1 (HGNC Symbol)

Synonyms

 FLAP-1, FLIIAP1, GCF-2, HUFI-1, TRIP

Description

 Leucine rich repeat (in FLII) interacting protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 237627576 - 237813682

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124831 (version 83.38)

Entrez gene

 9208

UniProt

 Q32MZ4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q32MZ4

Antibodypedia

 LRRFIP1 antibodies

PROTEIN BROWSER
LRRFIP1-001
LRRFIP1-002
LRRFIP1-003
LRRFIP1-004
LRRFIP1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LRRFIP1-001
ENSP00000244815
ENST00000244815
Q32MZ4 [Direct mapping]
Leucine-rich repeat flightless-interacting protein 1
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008150 [biological_process]
GO:0032481 [positive regulation of type I interferon production]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 784 aa
86.4 kDa 		No 0
LRRFIP1-002
ENSP00000310109
ENST00000308482
Q32MZ4 [Direct mapping]
Leucine-rich repeat flightless-interacting protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008150 [biological_process]
GO:0032481 [positive regulation of type I interferon production]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 640 aa
73.1 kDa 		No 0
LRRFIP1-003
ENSP00000375857
ENST00000392000
Q32MZ4 [Direct mapping]
Leucine-rich repeat flightless-interacting protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008150 [biological_process]
GO:0032481 [positive regulation of type I interferon production]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 808 aa
89.3 kDa 		No 0
LRRFIP1-004
ENSP00000289175
ENST00000289175
Q32MZ4 [Direct mapping]
Leucine-rich repeat flightless-interacting protein 1
A0A0F7NGI8 [Target identity:100%; Query identity:100%]
Leucine rich repeat (In FLII) interacting protein 1, isoform CRA_c; Leucine-rich repeat flightless-interacting protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008150 [biological_process]
GO:0032481 [positive regulation of type I interferon production]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 752 aa
82.7 kDa 		No 0
LRRFIP1-005
ENSP00000409431
ENST00000420665
C9JTC6 [Direct mapping]
Leucine-rich repeat flightless-interacting protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 149 aa
16.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.