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RAB17

GENERAL INFORMATION

Gene name

 RAB17

Gene description

 RAB17, member RAS oncogene family

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (BEWO, MCF7, SK-BR-3, SK-MEL-30)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in several different tissue types, including CNS and most glandular cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA035176
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), urothelial cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA035176

GENE INFORMATION

Gene name

 RAB17

Synonyms

Description

 RAB17, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 237574322 - 237601614

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124839 (version 83.38)

Entrez gene

 64284

UniProt

 Q9H0T7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H0T7

Antibodypedia

 RAB17 antibodies

PROTEIN BROWSER
RAB17-001
RAB17-005
RAB17-007
RAB17-008
RAB17-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB17-001
ENSP00000264601
ENST00000264601
Q9H0T7 [Direct mapping]
Ras-related protein Rab-17
A0A024R4A4 [Target identity:100%; Query identity:100%]
RAB17, member RAS oncogene family, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002415 [immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019003 [GDP binding]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0030425 [dendrite]
GO:0032401 [establishment of melanosome localization]
GO:0032402 [melanosome transport]
GO:0032456 [endocytic recycling]
GO:0032482 [Rab protein signal transduction]
GO:0042384 [cilium assembly]
GO:0042470 [melanosome]
GO:0043025 [neuronal cell body]
GO:0045056 [transcytosis]
GO:0046847 [filopodium assembly]
GO:0050773 [regulation of dendrite development]
GO:0051489 [regulation of filopodium assembly]
GO:0051963 [regulation of synapse assembly]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
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 212 aa
23.5 kDa 		No 0
RAB17-005
ENSP00000400240
ENST00000411462
C9J0T6 [Direct mapping]
Ras-related protein Rab-17
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030100 [regulation of endocytosis]
GO:0032456 [endocytic recycling]
GO:0032482 [Rab protein signal transduction]
GO:0051489 [regulation of filopodium assembly]
GO:0055038 [recycling endosome membrane]
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 130 aa
14.5 kDa 		No 0
RAB17-007
ENSP00000386792
ENST00000409576
B8ZZM5 [Direct mapping]
Ras-related protein Rab-17
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0030100 [regulation of endocytosis]
GO:0032456 [endocytic recycling]
GO:0032482 [Rab protein signal transduction]
GO:0051489 [regulation of filopodium assembly]
GO:0055038 [recycling endosome membrane]
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 53 aa
5.7 kDa 		No 0
RAB17-008
ENSP00000401495
ENST00000430445
H7C1P7 [Direct mapping]
Ras-related protein Rab-17
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030100 [regulation of endocytosis]
GO:0032456 [endocytic recycling]
GO:0032482 [Rab protein signal transduction]
GO:0051489 [regulation of filopodium assembly]
GO:0055038 [recycling endosome membrane]
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 141 aa
15.5 kDa 		No 0
RAB17-011
ENSP00000386589
ENST00000409822
Q9H0T7 [Direct mapping]
Ras-related protein Rab-17
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002415 [immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019003 [GDP binding]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0030425 [dendrite]
GO:0032401 [establishment of melanosome localization]
GO:0032402 [melanosome transport]
GO:0032456 [endocytic recycling]
GO:0032482 [Rab protein signal transduction]
GO:0042384 [cilium assembly]
GO:0042470 [melanosome]
GO:0043025 [neuronal cell body]
GO:0045056 [transcytosis]
GO:0046847 [filopodium assembly]
GO:0050773 [regulation of dendrite development]
GO:0051489 [regulation of filopodium assembly]
GO:0051963 [regulation of synapse assembly]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
Show all
 85 aa
9.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.