Expression of MYRF in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MYRF

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	MYRF
Gene description	Myelin regulatory factor
Protein class	Enzymes Plasma proteins Predicted membrane proteins Transcription factors
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A549, CACO-2, CAPAN-2, EFO-21)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, stomach)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	MYRF (HGNC Symbol)
Synonyms	C11orf9, MRF, Ndt80, pqn-47
Description	Myelin regulatory factor (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	61752642 - 61788518
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124920 (version 83.38)
Entrez gene	745
UniProt	Q9Y2G1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2G1
Antibodypedia	MYRF antibodies

PROTEIN BROWSER

MYRF-001	MYRF-002	MYRF-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYRF-001 ENSP00000278836 ENST00000278836	Q9Y2G1 [Direct mapping] Myelin regulatory factor Myelin regulatory factor, N-terminal Myelin regulatory factor, C-terminal Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Transcription factors Immunoglobulin fold Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0014003 [oligodendrocyte development] GO:0016021 [integral component of membrane] GO:0022010 [central nervous system myelination] GO:0031643 [positive regulation of myelination] GO:0032286 [central nervous system myelin maintenance] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048709 [oligodendrocyte differentiation] Show all	1151 aa 124.4 kDa	No	1
MYRF-002 ENSP00000265460 ENST00000265460	Q9Y2G1 [Direct mapping] Myelin regulatory factor Myelin regulatory factor, N-terminal Myelin regulatory factor, C-terminal Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Transcription factors Immunoglobulin fold Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0014003 [oligodendrocyte development] GO:0016021 [integral component of membrane] GO:0022010 [central nervous system myelination] GO:0031643 [positive regulation of myelination] GO:0032286 [central nervous system myelin maintenance] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048709 [oligodendrocyte differentiation] Show all	1111 aa 120.2 kDa	No	1
MYRF-003 ENSP00000374253 ENST00000389602	B4DHB2 [Direct mapping] Myelin regulatory factor; cDNA FLJ59324 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	537 aa 57.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.