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AHNAK

GENERAL INFORMATION

Gene name

 AHNAK

Gene description

 AHNAK nucleoprotein

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (TIME)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 3 antibodies.
HPA019010 , HPA019070 , HPA026643
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable) and pancreatic cancer (unfavourable).
Urothelial cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019010
HPA019070
HPA026643

GENE INFORMATION

Gene name

 AHNAK (HGNC Symbol)

Synonyms

 MGC5395

Description

 AHNAK nucleoprotein (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 q12.3

Chromosome location (bp)

 62433542 - 62556235

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000124942 (version 83.38)

Entrez gene

 79026

UniProt

 Q09666 (UniProt - Evidence at protein level)

neXtProt

 NX_Q09666

Antibodypedia

 AHNAK antibodies

PROTEIN BROWSER
AHNAK-001
AHNAK-005
AHNAK-007
AHNAK-009
AHNAK-010
AHNAK-011
AHNAK-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AHNAK-001
ENSP00000257247
ENST00000257247
Q09666 [Direct mapping]
Neuroblast differentiation-associated protein AHNAK
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030315 [T-tubule]
GO:0031982 [vesicle]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
GO:0043484 [regulation of RNA splicing]
GO:0044291 [cell-cell contact zone]
GO:0044548 [S100 protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045121 [membrane raft]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
GO:0097493 [structural molecule activity conferring elasticity]
GO:1901385 [regulation of voltage-gated calcium channel activity]
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 149 aa
16.1 kDa 		No 0
AHNAK-005
ENSP00000367263
ENST00000378024
Q09666 [Direct mapping]
Neuroblast differentiation-associated protein AHNAK
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030315 [T-tubule]
GO:0031982 [vesicle]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
GO:0043484 [regulation of RNA splicing]
GO:0044291 [cell-cell contact zone]
GO:0044548 [S100 protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045121 [membrane raft]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
GO:0097493 [structural molecule activity conferring elasticity]
GO:1901385 [regulation of voltage-gated calcium channel activity]
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 5890 aa
629.1 kDa 		No 0
AHNAK-007
ENSP00000433286
ENST00000530285
E9PLK4 [Direct mapping]
Neuroblast differentiation-associated protein AHNAK
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 144 aa
15.9 kDa 		No 0
AHNAK-009
ENSP00000435357
ENST00000528508
E9PKR9 [Direct mapping]
Neuroblast differentiation-associated protein AHNAK
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 123 aa
13.6 kDa 		No 0
AHNAK-010
ENSP00000436845
ENST00000531324
E9PQE3 [Direct mapping]
Neuroblast differentiation-associated protein AHNAK
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 86 aa
9.4 kDa 		No 0
AHNAK-011
ENSP00000433789
ENST00000530124
E9PJC6 [Direct mapping]
Neuroblast differentiation-associated protein AHNAK
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 131 aa
14.5 kDa 		No 0
AHNAK-013
ENSP00000433635
ENST00000533365
E9PJZ0 [Direct mapping]
Neuroblast differentiation-associated protein AHNAK
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 121 aa
13.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.