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SLC10A2

GENERAL INFORMATION

Gene name

 SLC10A2

Gene description

 Solute carrier family 10 (sodium/bile acid cotransporter), member 2

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (renal cancer)
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (duodenum, kidney, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 High membranous expression in small intestines.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA004795
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004795

GENE INFORMATION

Gene name

 SLC10A2 (HGNC Symbol)

Synonyms

 ASBT, ISBT

Description

 Solute carrier family 10 (sodium/bile acid cotransporter), member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]

Chromosome

 13

Cytoband

 q33.1

Chromosome location (bp)

 103043998 - 103066846

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125255 (version 83.38)

Entrez gene

 6555

UniProt

 Q12908 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12908

Antibodypedia

 SLC10A2 antibodies

PROTEIN BROWSER
SLC10A2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC10A2-001
ENSP00000245312
ENST00000245312
Q12908 [Direct mapping]
Ileal sodium/bile acid cotransporter
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Potential drug targets
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GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005902 [microvillus]
GO:0006810 [transport]
GO:0006814 [sodium ion transport]
GO:0008206 [bile acid metabolic process]
GO:0008508 [bile acid:sodium symporter activity]
GO:0015721 [bile acid and bile salt transport]
GO:0016020 [membrane]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
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 348 aa
37.7 kDa 		No 8

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.