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SOX21

GENERAL INFORMATION

Gene name

 SOX21

Gene description

 SRY (sex determining region Y)-box 21

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enhanced (AF22, NTERA-2, PC-3)
HPA (normal tissue):Group enriched (cerebral cortex, esophagus, skin, stomach)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in glioma (favourable) and cervical cancer (favourable).
Glioma p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SOX21 (HGNC Symbol)

Synonyms

 SOX25

Description

 SRY (sex determining region Y)-box 21 (HGNC Symbol)

Entrez gene summary

 SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]

Chromosome

 13

Cytoband

 q32.1

Chromosome location (bp)

 94709622 - 94712399

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000125285 (version 83.38)

Entrez gene

 11166

UniProt

 Q9Y651 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9Y651

Antibodypedia

 SOX21 antibodies

PROTEIN BROWSER
SOX21-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOX21-001
ENSP00000366144
ENST00000376945
Q9Y651 [Direct mapping]
Transcription factor SOX-21
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001942 [hair follicle development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0042633 [hair cycle]
GO:0043588 [skin development]
GO:0048863 [stem cell differentiation]
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 276 aa
28.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.