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ATP5S

GENERAL INFORMATION

Gene name

 ATP5S

Gene description

 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA046967
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ATP5S (HGNC Symbol)

Synonyms

 ATPW, HSU79253

Description

 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q21.3

Chromosome location (bp)

 50312326 - 50335558

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125375 (version 83.38)

Entrez gene

 27109

UniProt

 Q99766 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99766

Antibodypedia

 ATP5S antibodies

PROTEIN BROWSER
ATP5S-002
ATP5S-003
ATP5S-004
ATP5S-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP5S-002
ENSP00000245448
ENST00000245448
Q99766 [Direct mapping]
ATP synthase subunit s, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005743 [mitochondrial inner membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015992 [proton transport]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045263 [proton-transporting ATP synthase complex, coupling factor F(o)]
GO:0046872 [metal ion binding]
Show all
 127 aa
14.7 kDa 		No 0
ATP5S-003
ENSP00000308334
ENST00000311459
Q99766 [Direct mapping]
ATP synthase subunit s, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015992 [proton transport]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045263 [proton-transporting ATP synthase complex, coupling factor F(o)]
GO:0046872 [metal ion binding]
Show all
 215 aa
24.9 kDa 		No 0
ATP5S-004
ENSP00000389246
ENST00000426751
Q99766 [Direct mapping]
ATP synthase subunit s, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005743 [mitochondrial inner membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015992 [proton transport]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045263 [proton-transporting ATP synthase complex, coupling factor F(o)]
GO:0046872 [metal ion binding]
Show all
 136 aa
15.7 kDa 		No 0
ATP5S-011
ENSP00000351258
ENST00000358473
Q8WXQ4 [Direct mapping]
ATP synthase coupling factor B-like 1; ATP synthase subunit s, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 266 aa
29.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.