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Antibody staining mainly not consistent with RNA expression data. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Strong often granular staining in the cytoplasm was observed in most gastric cancers as well as cases of colorectal, pancreatic and female genital cancers. Cancer cells in general were negative.
GENE INFORMATION
Gene name
BMP4 (HGNC Symbol)
Synonyms
BMP2B
Description
Bone morphogenetic protein 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the bone morphogenetic protein (BMP) family of proteins, which is part of the transforming growth factor-beta (TGF-beta) superfamily. Members of the BMP family play an important role in bone and cartilage development. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
P12644 [Direct mapping] Bone morphogenetic protein 4 Q53XC5 [Target identity:100%; Query identity:100%] Bone morphogenetic protein 4; Bone morphogenetic protein 4, isoform CRA_a; Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human); Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human)
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000186 [activation of MAPKK activity] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001568 [blood vessel development] GO:0001649 [osteoblast differentiation] GO:0001656 [metanephros development] GO:0001657 [ureteric bud development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001707 [mesoderm formation] GO:0001759 [organ induction] GO:0001822 [kidney development] GO:0001823 [mesonephros development] GO:0001843 [neural tube closure] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001944 [vasculature development] GO:0001958 [endochondral ossification] GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:0002062 [chondrocyte differentiation] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0002320 [lymphoid progenitor cell differentiation] GO:0003014 [renal system process] GO:0003130 [BMP signaling pathway involved in heart induction] GO:0003139 [secondary heart field specification] GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0003323 [type B pancreatic cell development] GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0007182 [common-partner SMAD protein phosphorylation] GO:0007224 [smoothened signaling pathway] GO:0007281 [germ cell development] GO:0007420 [brain development] GO:0007500 [mesodermal cell fate determination] GO:0007507 [heart development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009612 [response to mechanical stimulus] GO:0009791 [post-embryonic development] GO:0009888 [tissue development] GO:0009948 [anterior/posterior axis specification] GO:0010159 [specification of organ position] GO:0010453 [regulation of cell fate commitment] GO:0010468 [regulation of gene expression] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0010942 [positive regulation of cell death] GO:0010976 [positive regulation of neuron projection development] GO:0014070 [response to organic cyclic compound] GO:0021537 [telencephalon development] GO:0021904 [dorsal/ventral neural tube patterning] GO:0021978 [telencephalon regionalization] GO:0021983 [pituitary gland development] GO:0030198 [extracellular matrix organization] GO:0030218 [erythrocyte differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030326 [embryonic limb morphogenesis] GO:0030335 [positive regulation of cell migration] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0030513 [positive regulation of BMP signaling pathway] GO:0030900 [forebrain development] GO:0031988 [membrane-bounded vesicle] GO:0032092 [positive regulation of protein binding] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0032355 [response to estradiol] GO:0032526 [response to retinoic acid] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0033085 [negative regulation of T cell differentiation in thymus] GO:0033088 [negative regulation of immature T cell proliferation in thymus] GO:0033574 [response to testosterone] GO:0034504 [protein localization to nucleus] GO:0034599 [cellular response to oxidative stress] GO:0035116 [embryonic hindlimb morphogenesis] GO:0035990 [tendon cell differentiation] GO:0035993 [deltoid tuberosity development] GO:0039706 [co-receptor binding] GO:0040007 [growth] GO:0042056 [chemoattractant activity] GO:0042060 [wound healing] GO:0042306 [regulation of protein import into nucleus] GO:0042326 [negative regulation of phosphorylation] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042476 [odontogenesis] GO:0042487 [regulation of odontogenesis of dentin-containing tooth] GO:0042733 [embryonic digit morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043010 [camera-type eye development] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043407 [negative regulation of MAP kinase activity] GO:0043587 [tongue morphogenesis] GO:0045165 [cell fate commitment] GO:0045595 [regulation of cell differentiation] GO:0045597 [positive regulation of cell differentiation] GO:0045603 [positive regulation of endothelial cell differentiation] GO:0045606 [positive regulation of epidermal cell differentiation] GO:0045662 [negative regulation of myoblast differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045778 [positive regulation of ossification] GO:0045786 [negative regulation of cell cycle] GO:0045839 [negative regulation of mitotic nuclear division] GO:0045843 [negative regulation of striated muscle tissue development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048286 [lung alveolus development] GO:0048333 [mesodermal cell differentiation] GO:0048392 [intermediate mesodermal cell differentiation] GO:0048593 [camera-type eye morphogenesis] GO:0048598 [embryonic morphogenesis] GO:0048646 [anatomical structure formation involved in morphogenesis] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048663 [neuron fate commitment] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048706 [embryonic skeletal system development] GO:0048715 [negative regulation of oligodendrocyte differentiation] GO:0048745 [smooth muscle tissue development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0050918 [positive chemotaxis] GO:0051145 [smooth muscle cell differentiation] GO:0051150 [regulation of smooth muscle cell differentiation] GO:0051384 [response to glucocorticoid] GO:0055020 [positive regulation of cardiac muscle fiber development] GO:0060033 [anatomical structure regression] GO:0060041 [retina development in camera-type eye] GO:0060113 [inner ear receptor cell differentiation] GO:0060197 [cloacal septation] GO:0060235 [lens induction in camera-type eye] GO:0060272 [embryonic skeletal joint morphogenesis] GO:0060348 [bone development] GO:0060363 [cranial suture morphogenesis] GO:0060391 [positive regulation of SMAD protein import into nucleus] GO:0060393 [regulation of pathway-restricted SMAD protein phosphorylation] GO:0060395 [SMAD protein signal transduction] GO:0060425 [lung morphogenesis] GO:0060429 [epithelium development] GO:0060433 [bronchus development] GO:0060438 [trachea development] GO:0060440 [trachea formation] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060442 [branching involved in prostate gland morphogenesis] GO:0060449 [bud elongation involved in lung branching] GO:0060462 [lung lobe development] GO:0060502 [epithelial cell proliferation involved in lung morphogenesis] GO:0060503 [bud dilation involved in lung branching] GO:0060512 [prostate gland morphogenesis] GO:0060548 [negative regulation of cell death] GO:0060592 [mammary gland formation] GO:0060684 [epithelial-mesenchymal cell signaling] GO:0060686 [negative regulation of prostatic bud formation] GO:0060687 [regulation of branching involved in prostate gland morphogenesis] GO:0060688 [regulation of morphogenesis of a branching structure] GO:0061035 [regulation of cartilage development] GO:0061036 [positive regulation of cartilage development] GO:0061047 [positive regulation of branching involved in lung morphogenesis] GO:0061149 [BMP signaling pathway involved in ureter morphogenesis] GO:0061151 [BMP signaling pathway involved in renal system segmentation] GO:0061155 [pulmonary artery endothelial tube morphogenesis] GO:0070244 [negative regulation of thymocyte apoptotic process] GO:0070368 [positive regulation of hepatocyte differentiation] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070700 [BMP receptor binding] GO:0071260 [cellular response to mechanical stimulus] GO:0071363 [cellular response to growth factor stimulus] GO:0071731 [response to nitric oxide] GO:0071773 [cellular response to BMP stimulus] GO:0071893 [BMP signaling pathway involved in nephric duct formation] GO:0072001 [renal system development] GO:0072015 [glomerular visceral epithelial cell development] GO:0072097 [negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway] GO:0072101 [specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway] GO:0072104 [glomerular capillary formation] GO:0072125 [negative regulation of glomerular mesangial cell proliferation] GO:0072138 [mesenchymal cell proliferation involved in ureteric bud development] GO:0072161 [mesenchymal cell differentiation involved in kidney development] GO:0072192 [ureter epithelial cell differentiation] GO:0072193 [ureter smooth muscle cell differentiation] GO:0072198 [mesenchymal cell proliferation involved in ureter development] GO:0072200 [negative regulation of mesenchymal cell proliferation involved in ureter development] GO:0072205 [metanephric collecting duct development] GO:0090184 [positive regulation of kidney development] GO:0090191 [negative regulation of branching involved in ureteric bud morphogenesis] GO:0090194 [negative regulation of glomerulus development] GO:0097067 [cellular response to thyroid hormone stimulus] GO:1901341 [positive regulation of store-operated calcium channel activity] GO:1902462 [positive regulation of mesenchymal stem cell proliferation] GO:2000005 [negative regulation of metanephric S-shaped body morphogenesis] GO:2000007 [negative regulation of metanephric comma-shaped body morphogenesis] GO:2000105 [positive regulation of DNA-dependent DNA replication] GO:2000137 [negative regulation of cell proliferation involved in heart morphogenesis] GO:2000353 [positive regulation of endothelial cell apoptotic process] GO:2001012 [mesenchymal cell differentiation involved in renal system development]
P12644 [Direct mapping] Bone morphogenetic protein 4 Q53XC5 [Target identity:100%; Query identity:100%] Bone morphogenetic protein 4; Bone morphogenetic protein 4, isoform CRA_a; Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human); Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human)
Show all
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000186 [activation of MAPKK activity] GO:0001649 [osteoblast differentiation] GO:0001657 [ureteric bud development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001822 [kidney development] GO:0001823 [mesonephros development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001958 [endochondral ossification] GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:0002062 [chondrocyte differentiation] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0002320 [lymphoid progenitor cell differentiation] GO:0003130 [BMP signaling pathway involved in heart induction] GO:0003139 [secondary heart field specification] GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0003323 [type B pancreatic cell development] GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007182 [common-partner SMAD protein phosphorylation] GO:0007224 [smoothened signaling pathway] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell proliferation] GO:0009791 [post-embryonic development] GO:0010453 [regulation of cell fate commitment] GO:0010595 [positive regulation of endothelial cell migration] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0010942 [positive regulation of cell death] GO:0021537 [telencephalon development] GO:0030198 [extracellular matrix organization] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0030513 [positive regulation of BMP signaling pathway] GO:0032092 [positive regulation of protein binding] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0033085 [negative regulation of T cell differentiation in thymus] GO:0033088 [negative regulation of immature T cell proliferation in thymus] GO:0034504 [protein localization to nucleus] GO:0035990 [tendon cell differentiation] GO:0035993 [deltoid tuberosity development] GO:0039706 [co-receptor binding] GO:0040007 [growth] GO:0042056 [chemoattractant activity] GO:0042306 [regulation of protein import into nucleus] GO:0042326 [negative regulation of phosphorylation] GO:0042476 [odontogenesis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043407 [negative regulation of MAP kinase activity] GO:0045606 [positive regulation of epidermal cell differentiation] GO:0045662 [negative regulation of myoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045778 [positive regulation of ossification] GO:0045786 [negative regulation of cell cycle] GO:0045839 [negative regulation of mitotic nuclear division] GO:0045843 [negative regulation of striated muscle tissue development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048286 [lung alveolus development] GO:0048392 [intermediate mesodermal cell differentiation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048745 [smooth muscle tissue development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050918 [positive chemotaxis] GO:0055020 [positive regulation of cardiac muscle fiber development] GO:0060391 [positive regulation of SMAD protein import into nucleus] GO:0060393 [regulation of pathway-restricted SMAD protein phosphorylation] GO:0060395 [SMAD protein signal transduction] GO:0060425 [lung morphogenesis] GO:0060433 [bronchus development] GO:0060438 [trachea development] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060502 [epithelial cell proliferation involved in lung morphogenesis] GO:0060503 [bud dilation involved in lung branching] GO:0060548 [negative regulation of cell death] GO:0061036 [positive regulation of cartilage development] GO:0061047 [positive regulation of branching involved in lung morphogenesis] GO:0061149 [BMP signaling pathway involved in ureter morphogenesis] GO:0061151 [BMP signaling pathway involved in renal system segmentation] GO:0061155 [pulmonary artery endothelial tube morphogenesis] GO:0070244 [negative regulation of thymocyte apoptotic process] GO:0070700 [BMP receptor binding] GO:0071773 [cellular response to BMP stimulus] GO:0071893 [BMP signaling pathway involved in nephric duct formation] GO:0072001 [renal system development] GO:0072097 [negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway] GO:0072101 [specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway] GO:0072104 [glomerular capillary formation] GO:0072125 [negative regulation of glomerular mesangial cell proliferation] GO:0072192 [ureter epithelial cell differentiation] GO:0072193 [ureter smooth muscle cell differentiation] GO:0072200 [negative regulation of mesenchymal cell proliferation involved in ureter development] GO:0072205 [metanephric collecting duct development] GO:0090184 [positive regulation of kidney development] GO:0090191 [negative regulation of branching involved in ureteric bud morphogenesis] GO:0090194 [negative regulation of glomerulus development] GO:2000005 [negative regulation of metanephric S-shaped body morphogenesis] GO:2000007 [negative regulation of metanephric comma-shaped body morphogenesis] GO:2000105 [positive regulation of DNA-dependent DNA replication] GO:2000137 [negative regulation of cell proliferation involved in heart morphogenesis]
P12644 [Direct mapping] Bone morphogenetic protein 4 Q53XC5 [Target identity:100%; Query identity:100%] Bone morphogenetic protein 4; Bone morphogenetic protein 4, isoform CRA_a; Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human); Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human)
Show all
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000186 [activation of MAPKK activity] GO:0001649 [osteoblast differentiation] GO:0001657 [ureteric bud development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001822 [kidney development] GO:0001823 [mesonephros development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001958 [endochondral ossification] GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:0002062 [chondrocyte differentiation] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0002320 [lymphoid progenitor cell differentiation] GO:0003130 [BMP signaling pathway involved in heart induction] GO:0003139 [secondary heart field specification] GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0003323 [type B pancreatic cell development] GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007182 [common-partner SMAD protein phosphorylation] GO:0007224 [smoothened signaling pathway] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell proliferation] GO:0009791 [post-embryonic development] GO:0010453 [regulation of cell fate commitment] GO:0010595 [positive regulation of endothelial cell migration] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0010942 [positive regulation of cell death] GO:0021537 [telencephalon development] GO:0030198 [extracellular matrix organization] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0030513 [positive regulation of BMP signaling pathway] GO:0032092 [positive regulation of protein binding] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0033085 [negative regulation of T cell differentiation in thymus] GO:0033088 [negative regulation of immature T cell proliferation in thymus] GO:0034504 [protein localization to nucleus] GO:0035990 [tendon cell differentiation] GO:0035993 [deltoid tuberosity development] GO:0039706 [co-receptor binding] GO:0040007 [growth] GO:0042056 [chemoattractant activity] GO:0042306 [regulation of protein import into nucleus] GO:0042326 [negative regulation of phosphorylation] GO:0042476 [odontogenesis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043407 [negative regulation of MAP kinase activity] GO:0045606 [positive regulation of epidermal cell differentiation] GO:0045662 [negative regulation of myoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045778 [positive regulation of ossification] GO:0045786 [negative regulation of cell cycle] GO:0045839 [negative regulation of mitotic nuclear division] GO:0045843 [negative regulation of striated muscle tissue development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048286 [lung alveolus development] GO:0048392 [intermediate mesodermal cell differentiation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048745 [smooth muscle tissue development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050918 [positive chemotaxis] GO:0055020 [positive regulation of cardiac muscle fiber development] GO:0060391 [positive regulation of SMAD protein import into nucleus] GO:0060393 [regulation of pathway-restricted SMAD protein phosphorylation] GO:0060395 [SMAD protein signal transduction] GO:0060425 [lung morphogenesis] GO:0060433 [bronchus development] GO:0060438 [trachea development] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060502 [epithelial cell proliferation involved in lung morphogenesis] GO:0060503 [bud dilation involved in lung branching] GO:0060548 [negative regulation of cell death] GO:0061036 [positive regulation of cartilage development] GO:0061047 [positive regulation of branching involved in lung morphogenesis] GO:0061149 [BMP signaling pathway involved in ureter morphogenesis] GO:0061151 [BMP signaling pathway involved in renal system segmentation] GO:0061155 [pulmonary artery endothelial tube morphogenesis] GO:0070244 [negative regulation of thymocyte apoptotic process] GO:0070700 [BMP receptor binding] GO:0071773 [cellular response to BMP stimulus] GO:0071893 [BMP signaling pathway involved in nephric duct formation] GO:0072001 [renal system development] GO:0072097 [negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway] GO:0072101 [specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway] GO:0072104 [glomerular capillary formation] GO:0072125 [negative regulation of glomerular mesangial cell proliferation] GO:0072192 [ureter epithelial cell differentiation] GO:0072193 [ureter smooth muscle cell differentiation] GO:0072200 [negative regulation of mesenchymal cell proliferation involved in ureter development] GO:0072205 [metanephric collecting duct development] GO:0090184 [positive regulation of kidney development] GO:0090191 [negative regulation of branching involved in ureteric bud morphogenesis] GO:0090194 [negative regulation of glomerulus development] GO:2000005 [negative regulation of metanephric S-shaped body morphogenesis] GO:2000007 [negative regulation of metanephric comma-shaped body morphogenesis] GO:2000105 [positive regulation of DNA-dependent DNA replication] GO:2000137 [negative regulation of cell proliferation involved in heart morphogenesis]
P12644 [Direct mapping] Bone morphogenetic protein 4 Q53XC5 [Target identity:100%; Query identity:100%] Bone morphogenetic protein 4; Bone morphogenetic protein 4, isoform CRA_a; Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human); Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human)
Show all
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000186 [activation of MAPKK activity] GO:0001649 [osteoblast differentiation] GO:0001657 [ureteric bud development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001822 [kidney development] GO:0001823 [mesonephros development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001958 [endochondral ossification] GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:0002062 [chondrocyte differentiation] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0002320 [lymphoid progenitor cell differentiation] GO:0003130 [BMP signaling pathway involved in heart induction] GO:0003139 [secondary heart field specification] GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0003323 [type B pancreatic cell development] GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007182 [common-partner SMAD protein phosphorylation] GO:0007224 [smoothened signaling pathway] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell proliferation] GO:0009791 [post-embryonic development] GO:0010453 [regulation of cell fate commitment] GO:0010595 [positive regulation of endothelial cell migration] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0010942 [positive regulation of cell death] GO:0021537 [telencephalon development] GO:0030198 [extracellular matrix organization] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0030513 [positive regulation of BMP signaling pathway] GO:0032092 [positive regulation of protein binding] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0033085 [negative regulation of T cell differentiation in thymus] GO:0033088 [negative regulation of immature T cell proliferation in thymus] GO:0034504 [protein localization to nucleus] GO:0035990 [tendon cell differentiation] GO:0035993 [deltoid tuberosity development] GO:0039706 [co-receptor binding] GO:0040007 [growth] GO:0042056 [chemoattractant activity] GO:0042306 [regulation of protein import into nucleus] GO:0042326 [negative regulation of phosphorylation] GO:0042476 [odontogenesis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043407 [negative regulation of MAP kinase activity] GO:0045606 [positive regulation of epidermal cell differentiation] GO:0045662 [negative regulation of myoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045778 [positive regulation of ossification] GO:0045786 [negative regulation of cell cycle] GO:0045839 [negative regulation of mitotic nuclear division] GO:0045843 [negative regulation of striated muscle tissue development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048286 [lung alveolus development] GO:0048392 [intermediate mesodermal cell differentiation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048745 [smooth muscle tissue development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050918 [positive chemotaxis] GO:0055020 [positive regulation of cardiac muscle fiber development] GO:0060391 [positive regulation of SMAD protein import into nucleus] GO:0060393 [regulation of pathway-restricted SMAD protein phosphorylation] GO:0060395 [SMAD protein signal transduction] GO:0060425 [lung morphogenesis] GO:0060433 [bronchus development] GO:0060438 [trachea development] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060502 [epithelial cell proliferation involved in lung morphogenesis] GO:0060503 [bud dilation involved in lung branching] GO:0060548 [negative regulation of cell death] GO:0061036 [positive regulation of cartilage development] GO:0061047 [positive regulation of branching involved in lung morphogenesis] GO:0061149 [BMP signaling pathway involved in ureter morphogenesis] GO:0061151 [BMP signaling pathway involved in renal system segmentation] GO:0061155 [pulmonary artery endothelial tube morphogenesis] GO:0070244 [negative regulation of thymocyte apoptotic process] GO:0070700 [BMP receptor binding] GO:0071773 [cellular response to BMP stimulus] GO:0071893 [BMP signaling pathway involved in nephric duct formation] GO:0072001 [renal system development] GO:0072097 [negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway] GO:0072101 [specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway] GO:0072104 [glomerular capillary formation] GO:0072125 [negative regulation of glomerular mesangial cell proliferation] GO:0072192 [ureter epithelial cell differentiation] GO:0072193 [ureter smooth muscle cell differentiation] GO:0072200 [negative regulation of mesenchymal cell proliferation involved in ureter development] GO:0072205 [metanephric collecting duct development] GO:0090184 [positive regulation of kidney development] GO:0090191 [negative regulation of branching involved in ureteric bud morphogenesis] GO:0090194 [negative regulation of glomerulus development] GO:2000005 [negative regulation of metanephric S-shaped body morphogenesis] GO:2000007 [negative regulation of metanephric comma-shaped body morphogenesis] GO:2000105 [positive regulation of DNA-dependent DNA replication] GO:2000137 [negative regulation of cell proliferation involved in heart morphogenesis]