Cell atlas - GRK4 - The Human Protein Atlas

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GRK4

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	GRK4
Gene description	G protein-coupled receptor kinase 4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA028737
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028737	A-431	Vesicles
	HPA028737	U-2 OS	Vesicles
	HPA028737	U-251 MG	No staining

GENE INFORMATION
Gene name	GRK4 (HGNC Symbol)
Synonyms	GPRK2L, GPRK4
Description	G protein-coupled receptor kinase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	2963608 - 3040747
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125388 (version 83.38)
Entrez gene	2868
UniProt	P32298 (UniProt - Evidence at protein level)
neXtProt	NX_P32298
Antibodypedia	GRK4 antibodies

PROTEIN BROWSER

GRK4-001	GRK4-002	GRK4-004	GRK4-005	GRK4-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRK4-001 ENSP00000381129 ENST00000398052	P32298 [Direct mapping] G protein-coupled receptor kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0002029 [desensitization of G-protein coupled receptor protein signaling pathway] GO:0002031 [G-protein coupled receptor internalization] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0007603 [phototransduction, visible light] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0030425 [dendrite] GO:0031623 [receptor internalization] GO:0043025 [neuronal cell body] GO:0050254 [rhodopsin kinase activity] GO:0097381 [photoreceptor disc membrane] Show all	578 aa 66.6 kDa	No	0
GRK4-002 ENSP00000381128 ENST00000398051	P32298 [Direct mapping] G protein-coupled receptor kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0007603 [phototransduction, visible light] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0031623 [receptor internalization] GO:0097381 [photoreceptor disc membrane] Show all	500 aa 57.7 kDa	No	0
GRK4-004 ENSP00000421650 ENST00000503518	D6REW5 [Direct mapping] G protein-coupled receptor kinase 4 Show all	Predicted intracellular proteins Show all		84 aa 9.2 kDa	No	0
GRK4-005 ENSP00000264764 ENST00000345167	P32298 [Direct mapping] G protein-coupled receptor kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0007603 [phototransduction, visible light] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0031623 [receptor internalization] GO:0097381 [photoreceptor disc membrane] Show all	546 aa 63 kDa	No	0
GRK4-012 ENSP00000427445 ENST00000504933	P32298 [Direct mapping] G protein-coupled receptor kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0007603 [phototransduction, visible light] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0031623 [receptor internalization] GO:0097381 [photoreceptor disc membrane] Show all	532 aa 61.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.