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MYH2

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GENERAL INFORMATION

Gene name

 MYH2

Gene description

 Myosin, heavy chain 2, skeletal muscle, adult

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 MYH2 (HGNC Symbol)

Synonyms

 IBM3, MYH2A, MYHas8, MyHC-2A, MyHC-IIa, MYHSA2

Description

 Myosin, heavy chain 2, skeletal muscle, adult (HGNC Symbol)

Entrez gene summary

 Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 10521148 - 10549957

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125414 (version 83.38)

Entrez gene

 4620

UniProt

 Q9UKX2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKX2

Antibodypedia

 MYH2 antibodies

PROTEIN BROWSER
MYH2-001
MYH2-002
MYH2-006
MYH2-009
MYH2-201
MYH2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYH2-001
ENSP00000245503
ENST00000245503
Q9UKX2 [Direct mapping]
Myosin-2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0001778 [plasma membrane repair]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005794 [Golgi apparatus]
GO:0005826 [actomyosin contractile ring]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0005911 [cell-cell junction]
GO:0006936 [muscle contraction]
GO:0008152 [metabolic process]
GO:0014823 [response to activity]
GO:0016459 [myosin complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0031672 [A band]
GO:0032982 [myosin filament]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0061024 [membrane organization]
GO:0070252 [actin-mediated cell contraction]
Show all
 1941 aa
223 kDa 		No 0
MYH2-002
ENSP00000399348
ENST00000420805
E7EX84 [Direct mapping]
Myosin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 182 aa
20.7 kDa 		No 0
MYH2-006
ENSP00000433944
ENST00000532183
Q9UKX2 [Direct mapping]
Myosin-2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0032982 [myosin filament]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0061024 [membrane organization]
Show all
 708 aa
79.9 kDa 		No 0
MYH2-009
ENSP00000463668
ENST00000578017
J3QLR0 [Direct mapping]
Myosin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 155 aa
17.6 kDa 		No 0
MYH2-201
ENSP00000380367
ENST00000397183
Q9UKX2 [Direct mapping]
Myosin-2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0032982 [myosin filament]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0061024 [membrane organization]
Show all
 1941 aa
223 kDa 		No 0
MYH2-202
ENSP00000482463
ENST00000622564
Q9UKX2 [Direct mapping]
Myosin-2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0032982 [myosin filament]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0061024 [membrane organization]
Show all
 708 aa
79.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.