Expression of MRPS7 in cancer - Summary - The Human Protein Atlas

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MRPS7

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MRPS7
Gene description	Mitochondrial ribosomal protein S7
Protein class	Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA022522 , HPA023007
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and liver cancer (unfavourable).
Colorectal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022522	HPA023007

GENE INFORMATION
Gene name	MRPS7 (HGNC Symbol)
Synonyms	MRP-S, RP-S7, RPMS7
Description	Mitochondrial ribosomal protein S7 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	75261674 - 75266373
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125445 (version 83.38)
Entrez gene	51081
UniProt	Q9Y2R9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2R9
Antibodypedia	MRPS7 antibodies

PROTEIN BROWSER

MRPS7-001	MRPS7-002	MRPS7-003	MRPS7-005	MRPS7-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPS7-001 ENSP00000245539 ENST00000245539	Q9Y2R9 [Direct mapping] 28S ribosomal protein S7, mitochondrial A0A024R8L0 [Target identity:100%; Query identity:100%] Mitochondrial ribosomal protein S7, isoform CRA_a Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000028 [ribosomal small subunit assembly] GO:0003729 [mRNA binding] GO:0003735 [structural constituent of ribosome] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005763 [mitochondrial small ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0019843 [rRNA binding] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	242 aa 28.1 kDa	No	0
MRPS7-002 ENSP00000463263 ENST00000579761	J3QKW2 [Direct mapping] 28S ribosomal protein S7, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006412 [translation] Show all	183 aa 20.8 kDa	No	0
MRPS7-003 ENSP00000463683 ENST00000579002	J3QLS3 [Direct mapping] 28S ribosomal protein S7, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006412 [translation] Show all	271 aa 31.7 kDa	No	0
MRPS7-005 ENSP00000463870 ENST00000581993	J3QQS1 [Direct mapping] 28S ribosomal protein S7, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006412 [translation] Show all	172 aa 19.9 kDa	No	0
MRPS7-006 ENSP00000462506 ENST00000584678	J3KSI8 [Direct mapping] 28S ribosomal protein S7, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006412 [translation] Show all	156 aa 18.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.