Expression of MIF4GD in cancer - Summary - The Human Protein Atlas

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MIF4GD

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MIF4GD
Gene description	MIF4G domain containing
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA051222
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051222

GENE INFORMATION
Gene name	MIF4GD (HGNC Symbol)
Synonyms	AD023, MGC45027, MIFD
Description	MIF4G domain containing (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	75266228 - 75271227
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125457 (version 83.38)
Entrez gene	57409
UniProt	A9UHW6 (UniProt - Evidence at protein level)
neXtProt	NX_A9UHW6
Antibodypedia	MIF4GD antibodies

PROTEIN BROWSER

MIF4GD-001	MIF4GD-002	MIF4GD-003	MIF4GD-004	MIF4GD-005	MIF4GD-006	MIF4GD-007	MIF4GD-009	MIF4GD-012	MIF4GD-013	MIF4GD-014	MIF4GD-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MIF4GD-001 ENSP00000462459 ENST00000579297	A9UHW6 [Direct mapping] MIF4G domain-containing protein Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006417 [regulation of translation] GO:0008022 [protein C-terminus binding] Show all	263 aa 30.1 kDa	No	0
MIF4GD-002 ENSP00000321625 ENST00000325102	A9UHW6 [Direct mapping] MIF4G domain-containing protein Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006417 [regulation of translation] GO:0008022 [protein C-terminus binding] Show all	222 aa 25.4 kDa	No	0
MIF4GD-003 ENSP00000245551 ENST00000245551	A9UHW6 [Direct mapping] MIF4G domain-containing protein Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006417 [regulation of translation] GO:0008022 [protein C-terminus binding] Show all	256 aa 29.4 kDa	No	0
MIF4GD-004 ENSP00000463334 ENST00000577542	A9UHW6 [Direct mapping] MIF4G domain-containing protein Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006417 [regulation of translation] GO:0008022 [protein C-terminus binding] Show all	263 aa 30.1 kDa	No	0
MIF4GD-005 ENSP00000462412 ENST00000580571	J3KSB8 [Direct mapping] MIF4G domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	170 aa 19.2 kDa	No	0
MIF4GD-006 ENSP00000463264 ENST00000579612	J3QKW3 [Direct mapping] MIF4G domain-containing protein Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 18.9 kDa	No	0
MIF4GD-007 ENSP00000464448 ENST00000580717	J3QRZ6 [Direct mapping] MIF4G domain-containing protein Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	205 aa 23.4 kDa	No	0
MIF4GD-009 ENSP00000463579 ENST00000579119	J3QLJ5 [Direct mapping] MIF4G domain-containing protein Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	251 aa 28.3 kDa	No	0
MIF4GD-012 ENSP00000462655 ENST00000579194	J3KSU6 [Direct mapping] MIF4G domain-containing protein Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	155 aa 17.8 kDa	No	0
MIF4GD-013 ENSP00000463493 ENST00000581777	J3QLD1 [Direct mapping] MIF4G domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	90 aa 10.2 kDa	No	0
MIF4GD-014 ENSP00000463629 ENST00000578305	J3QLN4 [Direct mapping] MIF4G domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		41 aa 4.6 kDa	No	0
MIF4GD-201 ENSP00000484245 ENST00000618645	A9UHW6 [Direct mapping] MIF4G domain-containing protein Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006417 [regulation of translation] GO:0008022 [protein C-terminus binding] Show all	222 aa 25.4 kDa	No	0

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