Fields »
ABOUT
HELP
BLOG
PSD4

GENERAL INFORMATION

Gene name

 PSD4

Gene description

 Pleckstrin and Sec7 domain containing 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membrnaous and cytoplasmic expression highly abundant in lymphoid cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA034722 , HPA034723
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable) and stomach cancer (favourable).
Liver cancer p<0.001
Stomach cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA034722
HPA034723

GENE INFORMATION

Gene name

 PSD4 (HGNC Symbol)

Synonyms

 EFA6B, TIC

Description

 Pleckstrin and Sec7 domain containing 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q14.1

Chromosome location (bp)

 113157325 - 113209396

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125637 (version 83.38)

Entrez gene

 23550

UniProt

 Q8NDX1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NDX1

Antibodypedia

 PSD4 antibodies

PROTEIN BROWSER
PSD4-001
PSD4-003
PSD4-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PSD4-001
ENSP00000245796
ENST00000245796
Q8NDX1 [Direct mapping]
PH and SEC7 domain-containing protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005543 [phospholipid binding]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1056 aa
116.2 kDa 		No 0
PSD4-003
ENSP00000413997
ENST00000441564
Q8NDX1 [Direct mapping]
PH and SEC7 domain-containing protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005543 [phospholipid binding]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1027 aa
113.1 kDa 		No 0
PSD4-010
ENSP00000386606
ENST00000409378
B8ZZZ5 [Direct mapping]
PH and SEC7 domain-containing protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0043547 [positive regulation of GTPase activity]
Show all
 178 aa
19.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.