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GTF2F1

GENERAL INFORMATION

Gene name

 GTF2F1

Gene description

 General transcription factor IIF, polypeptide 1, 74kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA022793
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and renal cancer (favourable).
Endometrial cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022793

GENE INFORMATION

Gene name

 GTF2F1 (HGNC Symbol)

Synonyms

 BTF4, RAP74, TF2F1, TFIIF

Description

 General transcription factor IIF, polypeptide 1, 74kDa (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 6379569 - 6393981

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125651 (version 83.38)

Entrez gene

 2962

UniProt

 P35269 (UniProt - Evidence at protein level)

neXtProt

 NX_P35269

Antibodypedia

 GTF2F1 antibodies

PROTEIN BROWSER
GTF2F1-001
GTF2F1-003
GTF2F1-005
GTF2F1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GTF2F1-001
ENSP00000377969
ENST00000394456
P35269 [Direct mapping]
General transcription factor IIF subunit 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000398 [mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005674 [transcription factor TFIIF complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0008134 [transcription factor binding]
GO:0008380 [RNA splicing]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0019211 [phosphatase activator activity]
GO:0030054 [cell junction]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0043085 [positive regulation of catalytic activity]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050434 [positive regulation of viral transcription]
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 517 aa
58.2 kDa 		No 0
GTF2F1-003
ENSP00000471542
ENST00000598607
M0R0Z3 [Direct mapping]
General transcription factor IIF subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0005634 [nucleus]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
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 127 aa
14.7 kDa 		No 0
GTF2F1-005
ENSP00000471403
ENST00000595047
M0R0R9 [Direct mapping]
General transcription factor IIF subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0005634 [nucleus]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0030054 [cell junction]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
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 381 aa
43.3 kDa 		No 0
GTF2F1-006
ENSP00000469091
ENST00000593678
M0QXD6 [Direct mapping]
General transcription factor IIF subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0005634 [nucleus]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
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 433 aa
48.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.