Expression of ALKBH7 in cancer - Summary

GENERAL INFORMATION
Gene name	ALKBH7
Gene description	AlkB homolog 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in glandular cells, most abundant in pancreas and testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA039571 , HPA039872
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA039571	HPA039872

GENE INFORMATION
Gene name	ALKBH7 (HGNC Symbol)
Synonyms	MGC10974, SPATA11
Description	AlkB homolog 7 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	6372433 - 6375251
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125652 (version 83.38)
Entrez gene	84266
UniProt	Q9BT30 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BT30
Antibodypedia	ALKBH7 antibodies

PROTEIN BROWSER

ALKBH7-001	ALKBH7-002	ALKBH7-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALKBH7-001 ENSP00000245812 ENST00000245812	Q9BT30 [Direct mapping] Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0010883 [regulation of lipid storage] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:1902445 [regulation of mitochondrial membrane permeability involved in programmed necrotic cell death] Show all	221 aa 24.5 kDa	No	0
ALKBH7-002 ENSP00000470542 ENST00000596657	M0QZH2 [Direct mapping] Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		79 aa 9 kDa	No	0
ALKBH7-003 ENSP00000470562 ENST00000599849	M0QZI0 [Direct mapping] Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		160 aa 17.6 kDa	No	0