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The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
Q15648 [Direct mapping] Mediator of RNA polymerase II transcription subunit 1
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Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000151 [ubiquitin ligase complex] GO:0000785 [chromatin] GO:0000902 [cell morphogenesis] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0001525 [angiogenesis] GO:0001701 [in utero embryonic development] GO:0001889 [liver development] GO:0001892 [embryonic placenta development] GO:0002088 [lens development in camera-type eye] GO:0002154 [thyroid hormone mediated signaling pathway] GO:0003222 [ventricular trabecula myocardium morphogenesis] GO:0003406 [retinal pigment epithelium development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006356 [regulation of transcription from RNA polymerase I promoter] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006590 [thyroid hormone generation] GO:0006702 [androgen biosynthetic process] GO:0007275 [multicellular organismal development] GO:0007420 [brain development] GO:0007507 [heart development] GO:0007595 [lactation] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0009887 [organ morphogenesis] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0010839 [negative regulation of keratinocyte proliferation] GO:0016020 [membrane] GO:0016567 [protein ubiquitination] GO:0016592 [mediator complex] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0030216 [keratinocyte differentiation] GO:0030224 [monocyte differentiation] GO:0030331 [estrogen receptor binding] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030375 [thyroid hormone receptor coactivator activity] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030521 [androgen receptor signaling pathway] GO:0031100 [organ regeneration] GO:0031490 [chromatin DNA binding] GO:0032403 [protein complex binding] GO:0032993 [protein-DNA complex] GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway] GO:0033160 [positive regulation of protein import into nucleus, translocation] GO:0033598 [mammary gland epithelial cell proliferation] GO:0033601 [positive regulation of mammary gland epithelial cell proliferation] GO:0035050 [embryonic heart tube development] GO:0035116 [embryonic hindlimb morphogenesis] GO:0035162 [embryonic hemopoiesis] GO:0035257 [nuclear hormone receptor binding] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0035729 [cellular response to hepatocyte growth factor stimulus] GO:0035855 [megakaryocyte development] GO:0036033 [mediator complex binding] GO:0042789 [mRNA transcription from RNA polymerase II promoter] GO:0042809 [vitamin D receptor binding] GO:0042974 [retinoic acid receptor binding] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043010 [camera-type eye development] GO:0043066 [negative regulation of apoptotic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045444 [fat cell differentiation] GO:0045618 [positive regulation of keratinocyte differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045665 [negative regulation of neuron differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046966 [thyroid hormone receptor binding] GO:0048821 [erythrocyte development] GO:0048822 [enucleate erythrocyte development] GO:0050693 [LBD domain binding] GO:0051726 [regulation of cell cycle] GO:0060335 [positive regulation of interferon-gamma-mediated signaling pathway] GO:0060744 [mammary gland branching involved in thelarche] GO:0060745 [mammary gland branching involved in pregnancy] GO:0060750 [epithelial cell proliferation involved in mammary gland duct elongation] GO:0061630 [ubiquitin protein ligase activity] GO:0070318 [positive regulation of G0 to G1 transition] GO:0070371 [ERK1 and ERK2 cascade] GO:0070562 [regulation of vitamin D receptor signaling pathway] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071383 [cellular response to steroid hormone stimulus] GO:0097067 [cellular response to thyroid hormone stimulus] GO:2000273 [positive regulation of receptor activity] GO:2000347 [positive regulation of hepatocyte proliferation] GO:2001141 [regulation of RNA biosynthetic process]