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CD70

GENERAL INFORMATION

Gene name

 CD70

Gene description

 CD70 molecule

Protein class

 Cancer-related genes
CD markers
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (renal cancer)
HPA (cell line):Cell line enhanced (SiHa, U-251 MG, U-266/70, U-266/84)
HPA (normal tissue):Tissue enhanced (appendix)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CD70 (HGNC Symbol)

Synonyms

 CD27L, CD27LG, TNFSF7

Description

 CD70 molecule (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 6583183 - 6604103

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125726 (version 83.38)

Entrez gene

 970

UniProt

 P32970 (UniProt - Evidence at protein level)

neXtProt

 NX_P32970

Antibodypedia

 CD70 antibodies

PROTEIN BROWSER
CD70-001
CD70-002
CD70-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD70-001
ENSP00000245903
ENST00000245903
P32970 [Direct mapping]
CD70 antigen
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CD markers
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0097191 [extrinsic apoptotic signaling pathway]
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 193 aa
21.1 kDa 		No 0
CD70-002
ENSP00000470805
ENST00000597430
M0QZW2 [Direct mapping]
CD70 antigen
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
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GO:0016021 [integral component of membrane]
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 65 aa
7.1 kDa 		No 1
CD70-003
ENSP00000395294
ENST00000423145
P32970 [Direct mapping]
CD70 antigen
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0097191 [extrinsic apoptotic signaling pathway]
Show all
 208 aa
23.4 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.