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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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C3
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

C3

Gene description

Complement component 3

Protein class

Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Distinct positivity in plasma.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 3 antibodies.
HPA003563 , HPA020432 , CAB004209
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
N/A
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

C3 (HGNC Symbol)

Synonyms

ARMD9, C3a, C3b, CPAMD1

Description

Complement component 3 (HGNC Symbol)

Entrez gene summary

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

6677704 - 6730562

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125730 (version 83.38)

Entrez gene

718

UniProt

P01024 (UniProt - Evidence at protein level)

neXtProt

NX_P01024

Antibodypedia

C3 antibodies

PROTEIN BROWSER

C3-001
C3-003
C3-014
C3-015
C3-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

C3-001
ENSP00000245907
ENST00000245907
P01024 [Direct mapping]
Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha' chain Complement C3c alpha' chain fragment 1 Complement C3dg fragment Complement C3g fragment Complement C3d fragment Complement C3f fragment Complement C3c alpha' chain fragment 2
V9HWA9 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 62p
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001798 [positive regulation of type IIa hypersensitivity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001970 [positive regulation of activation of membrane attack complex]
GO:0002507 [tolerance induction]
GO:0004866 [endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006631 [fatty acid metabolic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006956 [complement activation]
GO:0006957 [complement activation, alternative pathway]
GO:0006958 [complement activation, classical pathway]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008289 [lipid binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010828 [positive regulation of glucose transport]
GO:0010866 [regulation of triglyceride biosynthetic process]
GO:0010884 [positive regulation of lipid storage]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030449 [regulation of complement activation]
GO:0031715 [C5L2 anaphylatoxin chemotactic receptor binding]
GO:0032026 [response to magnesium ion]
GO:0032355 [response to estradiol]
GO:0032570 [response to progesterone]
GO:0043627 [response to estrogen]
GO:0045087 [innate immune response]
GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway]
GO:0045766 [positive regulation of angiogenesis]
GO:0048037 [cofactor binding]
GO:0048639 [positive regulation of developmental growth]
GO:0050766 [positive regulation of phagocytosis]
GO:0050776 [regulation of immune response]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:2000427 [positive regulation of apoptotic cell clearance]
Show all
1663 aa
187.1 kDa
Yes 0
C3-003
ENSP00000472044
ENST00000600744
M0R1Q1 [Direct mapping]
Complement C3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
103 aa
11.2 kDa
No 0
C3-014
ENSP00000469482
ENST00000602229
M0QXZ3 [Direct mapping]
Complement C3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
Show all
100 aa
11.6 kDa
No 0
C3-015
ENSP00000471384
ENST00000601008
M0R0Q9 [Direct mapping]
Complement C3
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
Show all
101 aa
11.2 kDa
No 0
C3-018
ENSP00000469744
ENST00000596548
M0QYC8 [Direct mapping]
Complement C3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
Show all
192 aa
21.7 kDa
No 0

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