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TNFSF14

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GENERAL INFORMATION

Gene name

 TNFSF14

Gene description

 Tumor necrosis factor (ligand) superfamily, member 14

Protein class

 CD markers
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (HDLM-2, U-937)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, U-937)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 TNFSF14 (HGNC Symbol)

Synonyms

 CD258, HVEM-L, LIGHT, LTg

Description

 Tumor necrosis factor (ligand) superfamily, member 14 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 6661253 - 6670588

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125735 (version 83.38)

Entrez gene

 8740

UniProt

 O43557 (UniProt - Evidence at protein level)

neXtProt

 NX_O43557

Antibodypedia

 TNFSF14 antibodies

PROTEIN BROWSER
TNFSF14-001
TNFSF14-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNFSF14-001
ENSP00000469049
ENST00000599359
O43557 [Direct mapping]
Tumor necrosis factor ligand superfamily member 14 Tumor necrosis factor ligand superfamily member 14, membrane form Tumor necrosis factor ligand superfamily member 14, soluble form
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0008588 [release of cytoplasmic sequestered NF-kappaB]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042098 [T cell proliferation]
GO:0042110 [T cell activation]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043029 [T cell homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0071260 [cellular response to mechanical stimulus]
GO:1901741 [positive regulation of myoblast fusion]
Show all
 240 aa
26.3 kDa 		No 1
TNFSF14-002
ENSP00000245912
ENST00000245912
O43557 [Direct mapping]
Tumor necrosis factor ligand superfamily member 14 Tumor necrosis factor ligand superfamily member 14, membrane form Tumor necrosis factor ligand superfamily member 14, soluble form
Show all
CD markers
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0008588 [release of cytoplasmic sequestered NF-kappaB]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042098 [T cell proliferation]
GO:0042110 [T cell activation]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043029 [T cell homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0071260 [cellular response to mechanical stimulus]
Show all
 204 aa
22.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.