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FOSB

GENERAL INFORMATION

Gene name

 FOSB

Gene description

 FBJ murine osteosarcoma viral oncogene homolog B

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB010267
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FOSB (HGNC Symbol)

Synonyms

 AP-1, DKFZp686C0818, G0S3, GOS3, GOSB, MGC42291

Description

 FBJ murine osteosarcoma viral oncogene homolog B (HGNC Symbol)

Entrez gene summary

 The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 45467995 - 45475179

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125740 (version 83.38)

Entrez gene

 2354

UniProt

 P53539 (UniProt - Evidence at transcript level)

neXtProt

 NX_P53539

Antibodypedia

 FOSB antibodies

PROTEIN BROWSER
«
FOSB-001
FOSB-002
FOSB-003
FOSB-004
FOSB-005
FOSB-006
FOSB-008
FOSB-011
FOSB-013
FOSB-015
FOSB-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOSB-001
ENSP00000245919
ENST00000353609
P53539 [Direct mapping]
Protein fosB
A0A024R0P6 [Target identity:100%; Query identity:100%]
FBJ murine osteosarcoma viral oncogene homolog B, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007565 [female pregnancy]
GO:0008134 [transcription factor binding]
GO:0009612 [response to mechanical stimulus]
GO:0032570 [response to progesterone]
GO:0032870 [cellular response to hormone stimulus]
GO:0042493 [response to drug]
GO:0043278 [response to morphine]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051412 [response to corticosterone]
GO:0051591 [response to cAMP]
GO:0071277 [cellular response to calcium ion]
Show all
 338 aa
35.9 kDa 		No 0
FOSB-002
ENSP00000407207
ENST00000417353
P53539 [Direct mapping]
Protein fosB
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0008134 [transcription factor binding]
Show all
 302 aa
31.5 kDa 		No 0
FOSB-003
ENSP00000466530
ENST00000591858
P53539 [Direct mapping]
Protein fosB
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
Show all
 299 aa
31.8 kDa 		No 0
FOSB-004
ENSP00000414177
ENST00000443841
P53539 [Direct mapping]
Protein fosB
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0008134 [transcription factor binding]
Show all
 195 aa
20.7 kDa 		No 0
FOSB-005
ENSP00000467497
ENST00000585836
P53539 [Direct mapping]
Protein fosB
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0008134 [transcription factor binding]
Show all
 263 aa
27.4 kDa 		No 0
FOSB-006
ENSP00000465068
ENST00000590335
K7EJ89 [Direct mapping]
Protein fosB
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 177 aa
18.1 kDa 		No 0
FOSB-008
ENSP00000468482
ENST00000592811
K7ERZ8 [Direct mapping]
Protein fosB
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
Show all
 188 aa
20.4 kDa 		No 0
FOSB-011
ENSP00000468207
ENST00000586615
P53539 [Direct mapping]
Protein fosB
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
Show all
 289 aa
31 kDa 		No 0
FOSB-013
ENSP00000465528
ENST00000589593
K7EKA0 [Direct mapping]
Protein fosB
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
Show all
 137 aa
14.7 kDa 		No 0
FOSB-015
ENSP00000465552
ENST00000592436
K7EKC1 [Direct mapping]
Protein fosB
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
Show all
 237 aa
25.4 kDa 		No 0
FOSB-201
ENSP00000485018
ENST00000615753
P53539 [Direct mapping]
Protein fosB
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
Show all
 291 aa
31 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.