Cell atlas - SYMPK - The Human Protein Atlas

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SYMPK

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SYMPK
Gene description	Symplekin
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Plasma membrane (supported), Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA041756 , HPA042449
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.

Main location

Nucleoplasm (supported)

Additional location

Plasma membrane (supported), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA041756	A-431	Nucleoplasm
		Plasma membrane
		Cytosol
HPA041756	U-2 OS	Nucleoplasm
		Plasma membrane
		Cytosol
HPA041756	U-251 MG	Nucleoplasm
		Plasma membrane
		Cytosol
HPA042449	A549	Nucleoplasm
HPA042449	A549	Cytosol
HPA042449	HEK 293	Nucleoplasm
HPA042449	HEK 293	Cytosol
HPA042449	U-2 OS	Nucleoplasm
HPA042449	U-2 OS	Cytosol

GENE INFORMATION
Gene name	SYMPK (HGNC Symbol)
Synonyms	SPK, SYM
Description	Symplekin (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	45815410 - 45863290
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125755 (version 83.38)
Entrez gene	8189
UniProt	Q92797 (UniProt - Evidence at protein level)
neXtProt	NX_Q92797
Antibodypedia	SYMPK antibodies

PROTEIN BROWSER

SYMPK-001	SYMPK-005	SYMPK-008	SYMPK-011	SYMPK-012	SYMPK-014	SYMPK-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYMPK-001 ENSP00000245934 ENST00000245934	Q92797 [Direct mapping] Symplekin A0A024R0R6 [Target identity:100%; Query identity:100%] Symplekin, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0006378 [mRNA polyadenylation] GO:0007155 [cell adhesion] GO:0035307 [positive regulation of protein dephosphorylation] Show all	1274 aa 141.1 kDa	No	0
SYMPK-005 ENSP00000479480 ENST00000599460	A0A087WUE9 [Direct mapping] Symplekin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	1058 aa 117.4 kDa	No	0
SYMPK-008 ENSP00000478599 ENST00000599814	A0A087WUE9 [Direct mapping] Symplekin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	1058 aa 117.4 kDa	No	0
SYMPK-011 ENSP00000471770 ENST00000594293	M0R1C2 [Direct mapping] Symplekin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 12.7 kDa	No	0
SYMPK-012 ENSP00000471694 ENST00000598059	M0R180 [Direct mapping] Symplekin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	137 aa 15.3 kDa	No	0
SYMPK-014 ENSP00000470977 ENST00000601600	M0R039 [Direct mapping] Symplekin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.2 kDa	No	0
SYMPK-021 ENSP00000469296 ENST00000602061	M0QXP5 [Direct mapping] Symplekin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	142 aa 15.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.