Fields »
ABOUT
HELP
BLOG
DEFB126

GENERAL INFORMATION

Gene name

 DEFB126

Gene description

 Defensin, beta 126

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (epididymis)
GTEx:Not detected
FANTOM5:Tissue enriched (epididymis)

Protein evidence

 Evidence at transcript level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (epididymis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (epididymis)

GENE INFORMATION

Gene name

 DEFB126 (HGNC Symbol)

Synonyms

 bA530N10.1, C20orf8, DEFB-26

Description

 Defensin, beta 126 (HGNC Symbol)

Entrez gene summary

 Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. The encoded protein is highly similar to an epididymal-specific secretory protein (ESP13.2) from cynomolgus monkey. Mutation of this gene is associated with impaired sperm function. [provided by RefSeq, Nov 2014]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 142369 - 145751

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000125788 (version 83.38)

Entrez gene

 81623

UniProt

 Q9BYW3 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9BYW3

Antibodypedia

 DEFB126 antibodies

PROTEIN BROWSER
DEFB126-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DEFB126-001
ENSP00000371835
ENST00000382398
Q9BYW3 [Direct mapping]
Beta-defensin 126
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005576 [extracellular region]
GO:0009986 [cell surface]
GO:0030112 [glycocalyx]
GO:0042742 [defense response to bacterium]
GO:0045087 [innate immune response]
Show all
 111 aa
12.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.