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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Validation

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Validation

Method

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Cancer

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Detectable

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Detectable

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Detectable

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Column

 
 
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FOXA2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

FOXA2

Gene description

Forkhead box A2

Protein class

Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (cervix, uterine, lung, stomach)
GTEx:Tissue enhanced (liver, pancreas, stomach)
FANTOM5:Group enriched (gallbladder, liver, lung, pancreas)

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB001388
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, lung, stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver, pancreas, stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (gallbladder, liver, lung, pancreas)

GENE INFORMATION

Gene name

FOXA2 (HGNC Symbol)

Synonyms

HNF3B

Description

Forkhead box A2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Chromosome

20

Cytoband

p11.21

Chromosome location (bp)

22581005 - 22585455

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125798 (version 83.38)

Entrez gene

3170

UniProt

Q9Y261 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y261

Antibodypedia

FOXA2 antibodies

PROTEIN BROWSER

FOXA2-001
FOXA2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FOXA2-001
ENSP00000366319
ENST00000377115
Q9Y261 [Direct mapping]
Hepatocyte nuclear factor 3-beta
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000432 [positive regulation of transcription from RNA polymerase II promoter by glucose]
GO:0000433 [negative regulation of transcription from RNA polymerase II promoter by glucose]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001708 [cell fate specification]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008344 [adult locomotory behavior]
GO:0009653 [anatomical structure morphogenesis]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0016568 [chromatin modification]
GO:0019904 [protein domain specific binding]
GO:0030154 [cell differentiation]
GO:0030193 [regulation of blood coagulation]
GO:0031018 [endocrine pancreas development]
GO:0033132 [negative regulation of glucokinase activity]
GO:0040019 [positive regulation of embryonic development]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0070741 [response to interleukin-6]
GO:0071542 [dopaminergic neuron differentiation]
GO:0090009 [primitive streak formation]
GO:2000049 [positive regulation of cell-cell adhesion mediated by cadherin]
GO:2000543 [positive regulation of gastrulation]
GO:2000971 [negative regulation of detection of glucose]
Show all
457 aa
48.3 kDa
No 0
FOXA2-002
ENSP00000400341
ENST00000419308
Q9Y261 [Direct mapping]
Hepatocyte nuclear factor 3-beta
B0ZTD4 [Target identity:100%; Query identity:100%]
Forkhead box A2; Forkhead box A2, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000432 [positive regulation of transcription from RNA polymerase II promoter by glucose]
GO:0000433 [negative regulation of transcription from RNA polymerase II promoter by glucose]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001701 [in utero embryonic development]
GO:0001705 [ectoderm formation]
GO:0001708 [cell fate specification]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0007389 [pattern specification process]
GO:0008134 [transcription factor binding]
GO:0008344 [adult locomotory behavior]
GO:0009653 [anatomical structure morphogenesis]
GO:0009952 [anterior/posterior pattern specification]
GO:0009953 [dorsal/ventral pattern formation]
GO:0010468 [regulation of gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0016568 [chromatin modification]
GO:0019216 [regulation of lipid metabolic process]
GO:0019218 [regulation of steroid metabolic process]
GO:0019904 [protein domain specific binding]
GO:0021533 [cell differentiation in hindbrain]
GO:0021904 [dorsal/ventral neural tube patterning]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030193 [regulation of blood coagulation]
GO:0030324 [lung development]
GO:0031018 [endocrine pancreas development]
GO:0032525 [somite rostral/caudal axis specification]
GO:0033132 [negative regulation of glucokinase activity]
GO:0040019 [positive regulation of embryonic development]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048468 [cell development]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048665 [neuron fate specification]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
GO:0060487 [lung epithelial cell differentiation]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0061448 [connective tissue development]
GO:0070741 [response to interleukin-6]
GO:0071542 [dopaminergic neuron differentiation]
GO:0090009 [primitive streak formation]
GO:2000049 [positive regulation of cell-cell adhesion mediated by cadherin]
GO:2000543 [positive regulation of gastrulation]
GO:2000971 [negative regulation of detection of glucose]
Show all
463 aa
48.9 kDa
No 0

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