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GZF1

GENERAL INFORMATION

Gene name

 GZF1

Gene description

 GDNF-inducible zinc finger protein 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA024520
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA024520

GENE INFORMATION

Gene name

 GZF1 (HGNC Symbol)

Synonyms

 dJ322G13.2, ZBTB23, ZNF336

Description

 GDNF-inducible zinc finger protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 20

Cytoband

 p11.21

Chromosome location (bp)

 23362182 - 23373063

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125812 (version 83.38)

Entrez gene

 64412

UniProt

 Q9H116 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H116

Antibodypedia

 GZF1 antibodies

PROTEIN BROWSER
GZF1-003
GZF1-004
GZF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GZF1-003
ENSP00000338290
ENST00000338121
Q9H116 [Direct mapping]
GDNF-inducible zinc finger protein 1
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001206 [transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 711 aa
80.5 kDa 		No 0
GZF1-004
ENSP00000410009
ENST00000424216
Q5JXG1 [Direct mapping]
GDNF-inducible zinc finger protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 48 aa
5.4 kDa 		No 0
GZF1-201
ENSP00000366250
ENST00000377051
Q9H116 [Direct mapping]
GDNF-inducible zinc finger protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001206 [transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 711 aa
80.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.