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DTD1

GENERAL INFORMATION

Gene name

 DTD1

Gene description

 D-tyrosyl-tRNA deacylase 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA040981
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DTD1 (HGNC Symbol)

Synonyms

 bA379J5.3, bA555E18.1, C20orf88, DUEB, HARS2, MGC119131, MGC41905, pqn-68

Description

 D-tyrosyl-tRNA deacylase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. [provided by RefSeq, Dec 2015]

Chromosome

 20

Cytoband

 p11.23

Chromosome location (bp)

 18567453 - 18763917

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125821 (version 83.38)

Entrez gene

 92675

UniProt

 Q8TEA8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TEA8

Antibodypedia

 DTD1 antibodies

PROTEIN BROWSER
DTD1-001
DTD1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DTD1-001
ENSP00000366672
ENST00000377452
Q8TEA8 [Direct mapping]
D-tyrosyl-tRNA(Tyr) deacylase 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006399 [tRNA metabolic process]
GO:0006450 [regulation of translational fidelity]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0019478 [D-amino acid catabolic process]
GO:0046872 [metal ion binding]
GO:0051500 [D-tyrosyl-tRNA(Tyr) deacylase activity]
Show all
 209 aa
23.4 kDa 		No 0
DTD1-003
ENSP00000482916
ENST00000618693
A0A087WZV9 [Direct mapping]
D-tyrosyl-tRNA(Tyr) deacylase
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   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0005737 [cytoplasm]
GO:0006399 [tRNA metabolic process]
GO:0006450 [regulation of translational fidelity]
GO:0016021 [integral component of membrane]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0019478 [D-amino acid catabolic process]
GO:0051500 [D-tyrosyl-tRNA(Tyr) deacylase activity]
Show all
 223 aa
25.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.