Expression of RRBP1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

RRBP1

premium

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RRBP1
Gene description	Ribosome binding protein 1
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA009026 , HPA011924
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and urothelial cancer (unfavourable).
Endometrial cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA009026	HPA011924

GENE INFORMATION
Gene name	RRBP1 (HGNC Symbol)
Synonyms	ES/130, hES
Description	Ribosome binding protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]
Chromosome	20
Cytoband	p12.1
Chromosome location (bp)	17613678 - 17682295
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125844 (version 83.38)
Entrez gene	6238
UniProt	Q9P2E9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P2E9
Antibodypedia	RRBP1 antibodies

PROTEIN BROWSER

RRBP1-001	RRBP1-002	RRBP1-003	RRBP1-005	RRBP1-007	RRBP1-201	RRBP1-202	RRBP1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RRBP1-001 ENSP00000354045 ENST00000360807	Q9P2E9 [Direct mapping] Ribosome-binding protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0004872 [receptor activity] GO:0005783 [endoplasmic reticulum] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0044822 [poly(A) RNA binding] Show all	977 aa 108.6 kDa	No	1
RRBP1-002 ENSP00000367044 ENST00000377813	A0A0A0MRV0 [Direct mapping] Ribosome-binding protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	1410 aa 152.5 kDa	No	1
RRBP1-003 ENSP00000381762 ENST00000398782	A2A2S5 [Direct mapping] Ribosome-binding protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	300 aa 31.7 kDa	No	0
RRBP1-005 ENSP00000478324 ENST00000470422	A0A087WU26 [Direct mapping] Ribosome-binding protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		346 aa 38.7 kDa	No	0
RRBP1-007 ENSP00000401206 ENST00000455029	F8W7S5 [Direct mapping] Ribosome-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] Show all	751 aa 84.3 kDa	No	0
RRBP1-201 ENSP00000246043 ENST00000246043	A0A0A0MRV0 [Direct mapping] Ribosome-binding protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	1410 aa 152.5 kDa	No	1
RRBP1-202 ENSP00000367038 ENST00000377807	Q9P2E9 [Direct mapping] Ribosome-binding protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0044822 [poly(A) RNA binding] Show all	977 aa 108.6 kDa	No	1
RRBP1-203 ENSP00000479709 ENST00000610403	A0A087WVV2 [Direct mapping] Ribosome-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		934 aa 102.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.