Expression of GFRA4 in cancer - Summary - The Human Protein Atlas

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GFRA4

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	GFRA4
Gene description	GDNF family receptor alpha 4
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (endometrial cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (thyroid gland)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	GFRA4
Synonyms
Description	GDNF family receptor alpha 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	3659292 - 3663399
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125861 (version 83.38)
Entrez gene	64096
UniProt	Q9GZZ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZZ7
Antibodypedia	GFRA4 antibodies

PROTEIN BROWSER

GFRA4-001	GFRA4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GFRA4-001 ENSP00000290417 ENST00000290417	Q9GZZ7 [Direct mapping] GDNF family receptor alpha-4 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005886 [plasma membrane] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	269 aa 28.7 kDa	Yes	0
GFRA4-002 ENSP00000313423 ENST00000319242	Q9GZZ7 [Direct mapping] GDNF family receptor alpha-4 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0016167 [glial cell-derived neurotrophic factor receptor activity] GO:0030279 [negative regulation of ossification] GO:0031225 [anchored component of membrane] GO:0035860 [glial cell-derived neurotrophic factor receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	299 aa 31.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.