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SNRPB2

GENERAL INFORMATION

Gene name

 SNRPB2

Gene description

 Small nuclear ribonucleoprotein polypeptide B

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SNRPB2 (HGNC Symbol)

Synonyms

 Msl1

Description

 Small nuclear ribonucleoprotein polypeptide B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p12.1

Chromosome location (bp)

 16729961 - 16742563

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125870 (version 83.38)

Entrez gene

 6629

UniProt

 P08579 (UniProt - Evidence at protein level)

neXtProt

 NX_P08579

Antibodypedia

 SNRPB2 antibodies

PROTEIN BROWSER
SNRPB2-001
SNRPB2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNRPB2-001
ENSP00000246071
ENST00000246071
P08579 [Direct mapping]
U2 small nuclear ribonucleoprotein B''
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005686 [U2 snRNP]
GO:0005730 [nucleolus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0035614 [snRNA stem-loop binding]
GO:0071013 [catalytic step 2 spliceosome]
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 225 aa
25.5 kDa 		No 0
SNRPB2-002
ENSP00000367178
ENST00000377943
P08579 [Direct mapping]
U2 small nuclear ribonucleoprotein B''
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005686 [U2 snRNP]
GO:0005730 [nucleolus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0035614 [snRNA stem-loop binding]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 225 aa
25.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.