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MCM8

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GENERAL INFORMATION

Gene name

 MCM8

Gene description

 Minichromosome maintenance 8 homologous recombination repair factor

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA045141
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA045141 A-431 Nucleus Intensity
HPA045141 U-251 MG No staining    

GENE INFORMATION

Gene name

 MCM8 (HGNC Symbol)

Synonyms

 C20orf154, dJ967N21.5, MGC119522, MGC119523, MGC12866, MGC4816, REC

Description

 Minichromosome maintenance 8 homologous recombination repair factor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]

Chromosome

 20

Cytoband

 p12.3

Chromosome location (bp)

 5950652 - 5998977

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125885 (version 83.38)

Entrez gene

 84515

UniProt

 Q9UJA3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJA3

Antibodypedia

 MCM8 antibodies

PROTEIN BROWSER
MCM8-001
MCM8-002
MCM8-201
MCM8-202
MCM8-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MCM8-001
ENSP00000478141
ENST00000610722
Q9UJA3 [Direct mapping]
DNA helicase MCM8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007292 [female gamete generation]
GO:0048232 [male gamete generation]
GO:0097362 [MCM8-MCM9 complex]
Show all
 840 aa
93.7 kDa 		No 0
MCM8-002
ENSP00000265187
ENST00000265187
Q9UJA3 [Direct mapping]
DNA helicase MCM8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007292 [female gamete generation]
GO:0048232 [male gamete generation]
GO:0097362 [MCM8-MCM9 complex]
Show all
 824 aa
91.8 kDa 		No 0
MCM8-201
ENSP00000368161
ENST00000378883
Q9UJA3 [Direct mapping]
DNA helicase MCM8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007292 [female gamete generation]
GO:0048232 [male gamete generation]
GO:0097362 [MCM8-MCM9 complex]
Show all
 793 aa
88.8 kDa 		No 0
MCM8-202
ENSP00000368164
ENST00000378886
Q9UJA3 [Direct mapping]
DNA helicase MCM8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007292 [female gamete generation]
GO:0048232 [male gamete generation]
GO:0097362 [MCM8-MCM9 complex]
Show all
 880 aa
97.9 kDa 		No 0
MCM8-203
ENSP00000368174
ENST00000378896
Q9UJA3 [Direct mapping]
DNA helicase MCM8
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007292 [female gamete generation]
GO:0048232 [male gamete generation]
GO:0097362 [MCM8-MCM9 complex]
Show all
 840 aa
93.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.