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CITED1

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GENERAL INFORMATION

Gene name

 CITED1

Gene description

 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (SK-MEL-30, AN3-CA)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA049051
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-MEL-30, AN3-CA)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (supported)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA049051 PC-3 Nucleus
Cytosol
HPA049051 SK-MEL-30 Nucleoplasm
Cytosol
HPA049051 U-2 OS Cytosol

GENE INFORMATION

Gene name

 CITED1 (HGNC Symbol)

Synonyms

 MSG1

Description

 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 72301638 - 72307187

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125931 (version 83.38)

Entrez gene

 4435

UniProt

 Q99966 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99966

Antibodypedia

 CITED1 antibodies

PROTEIN BROWSER
CITED1-001
CITED1-002
CITED1-003
CITED1-004
CITED1-005
CITED1-006
CITED1-007
CITED1-008
CITED1-201
CITED1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CITED1-001
ENSP00000362721
ENST00000373619
Q99966 [Direct mapping]
Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001890 [placenta development]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030318 [melanocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0034097 [response to cytokine]
GO:0034341 [response to interferon-gamma]
GO:0042438 [melanin biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0043473 [pigmentation]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043627 [response to estrogen]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050693 [LBD domain binding]
GO:0051591 [response to cAMP]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060395 [SMAD protein signal transduction]
GO:0070410 [co-SMAD binding]
GO:0070555 [response to interleukin-1]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070741 [response to interleukin-6]
GO:0071104 [response to interleukin-9]
GO:0071105 [response to interleukin-11]
GO:0071107 [response to parathyroid hormone]
GO:0071559 [response to transforming growth factor beta]
Show all
 193 aa
19.9 kDa 		No 0
CITED1-002
ENSP00000246139
ENST00000246139
Q99966 [Direct mapping]
Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001890 [placenta development]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030318 [melanocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0034097 [response to cytokine]
GO:0034341 [response to interferon-gamma]
GO:0042438 [melanin biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0043473 [pigmentation]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043627 [response to estrogen]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050693 [LBD domain binding]
GO:0051591 [response to cAMP]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060395 [SMAD protein signal transduction]
GO:0070410 [co-SMAD binding]
GO:0070555 [response to interleukin-1]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070741 [response to interleukin-6]
GO:0071104 [response to interleukin-9]
GO:0071105 [response to interleukin-11]
GO:0071107 [response to parathyroid hormone]
GO:0071559 [response to transforming growth factor beta]
Show all
 193 aa
19.9 kDa 		No 0
CITED1-003
ENSP00000401764
ENST00000453707
Q99966 [Direct mapping]
Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000578 [embryonic axis specification]
GO:0001570 [vasculogenesis]
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001890 [placenta development]
GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007420 [brain development]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030318 [melanocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0034097 [response to cytokine]
GO:0034341 [response to interferon-gamma]
GO:0042438 [melanin biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0043473 [pigmentation]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043627 [response to estrogen]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050693 [LBD domain binding]
GO:0051591 [response to cAMP]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060395 [SMAD protein signal transduction]
GO:0060711 [labyrinthine layer development]
GO:0060712 [spongiotrophoblast layer development]
GO:0070410 [co-SMAD binding]
GO:0070555 [response to interleukin-1]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070741 [response to interleukin-6]
GO:0071104 [response to interleukin-9]
GO:0071105 [response to interleukin-11]
GO:0071107 [response to parathyroid hormone]
GO:0071559 [response to transforming growth factor beta]
Show all
 219 aa
22.6 kDa 		No 0
CITED1-004
ENSP00000412769
ENST00000454225
C9J1P6 [Direct mapping]
Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 59 aa
6.2 kDa 		No 0
CITED1-005
ENSP00000405765
ENST00000450875
C9J7P8 [Direct mapping]
Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 109 aa
11 kDa 		No 0
CITED1-006
ENSP00000391407
ENST00000427412
C9J300 [Direct mapping]
Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 138 aa
14.2 kDa 		No 0
CITED1-007
ENSP00000414781
ENST00000417400
C9JRD8 [Direct mapping]
Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 141 aa
14.2 kDa 		No 0
CITED1-008
ENSP00000407496
ENST00000429794
H7C2S6 [Direct mapping]
Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 106 aa
11.2 kDa 		No 0
CITED1-201
ENSP00000388548
ENST00000431381
Q99966 [Direct mapping]
Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001890 [placenta development]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030318 [melanocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0034097 [response to cytokine]
GO:0034341 [response to interferon-gamma]
GO:0042438 [melanin biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0043473 [pigmentation]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043627 [response to estrogen]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050693 [LBD domain binding]
GO:0051591 [response to cAMP]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060395 [SMAD protein signal transduction]
GO:0070410 [co-SMAD binding]
GO:0070555 [response to interleukin-1]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070741 [response to interleukin-6]
GO:0071104 [response to interleukin-9]
GO:0071105 [response to interleukin-11]
GO:0071107 [response to parathyroid hormone]
GO:0071559 [response to transforming growth factor beta]
Show all
 219 aa
22.6 kDa 		No 0
CITED1-202
ENSP00000403274
ENST00000445983
Q99966 [Direct mapping]
Cbp/p300-interacting transactivator 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001890 [placenta development]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030318 [melanocyte differentiation]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0034097 [response to cytokine]
GO:0034341 [response to interferon-gamma]
GO:0042438 [melanin biosynthetic process]
GO:0042803 [protein homodimerization activity]
GO:0043473 [pigmentation]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043627 [response to estrogen]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050693 [LBD domain binding]
GO:0051591 [response to cAMP]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060395 [SMAD protein signal transduction]
GO:0070410 [co-SMAD binding]
GO:0070555 [response to interleukin-1]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070741 [response to interleukin-6]
GO:0071104 [response to interleukin-9]
GO:0071105 [response to interleukin-11]
GO:0071107 [response to parathyroid hormone]
GO:0071559 [response to transforming growth factor beta]
Show all
 193 aa
19.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.