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MMP24

GENERAL INFORMATION

Gene name

 MMP24

Gene description

 Matrix metallopeptidase 24 (membrane-inserted)

Protein class

 Enzymes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (A549, CACO-2)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MMP24 (HGNC Symbol)

Synonyms

 MT5-MMP

Description

 Matrix metallopeptidase 24 (membrane-inserted) (HGNC Symbol)

Entrez gene summary

 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q11.22

Chromosome location (bp)

 35226654 - 35277000

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000125966 (version 83.38)

Entrez gene

 10893

UniProt

 Q9Y5R2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9Y5R2

Antibodypedia

 MMP24 antibodies

PROTEIN BROWSER
MMP24-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MMP24-001
ENSP00000246186
ENST00000246186
Q9Y5R2 [Direct mapping]
Matrix metalloproteinase-24 Processed matrix metalloproteinase-24
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Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0008047 [enzyme activator activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0010001 [glial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0032588 [trans-Golgi network membrane]
GO:0043085 [positive regulation of catalytic activity]
GO:0044331 [cell-cell adhesion mediated by cadherin]
GO:0045296 [cadherin binding]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0070062 [extracellular exosome]
GO:0097150 [neuronal stem cell population maintenance]
GO:0098609 [cell-cell adhesion]
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 645 aa
73.2 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.