Cell atlas - EIF2S2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	EIF2S2
Gene description	Eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)
Additional location	In addition localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA041262 , HPA041332
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum. In addition localized to the nucleoli.

Main location

Endoplasmic reticulum (supported)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA041262	Hep G2	Endoplasmic reticulum
HPA041262	PC-3	No staining
HPA041262	U-2 OS	Endoplasmic reticulum
HPA041332	CACO-2	Nucleoli
HPA041332	CACO-2	Endoplasmic reticulum
HPA041332	PC-3	Nucleoli
HPA041332	PC-3	Endoplasmic reticulum
HPA041332	U-2 OS	Nucleoli
HPA041332	U-2 OS	Endoplasmic reticulum

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000074656 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA041262	NIH 3T3	Endoplasmic reticulum
	HPA041332	NIH 3T3	No staining

GENE INFORMATION
Gene name	EIF2S2 (HGNC Symbol)
Synonyms	EIF2, EIF2beta, PPP1R67
Description	Eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa (HGNC Symbol)
Entrez gene summary	Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Chromosome	20
Cytoband	q11.22
Chromosome location (bp)	34088298 - 34112332
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125977 (version 83.38)
Entrez gene	8894
UniProt	P20042 (UniProt - Evidence at protein level)
neXtProt	NX_P20042
Antibodypedia	EIF2S2 antibodies

PROTEIN BROWSER

EIF2S2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF2S2-001 ENSP00000364119 ENST00000374980	P20042 [Direct mapping] Eukaryotic translation initiation factor 2 subunit 2 Q6IBR8 [Target identity:100%; Query identity:100%] EIF2S2 protein; Eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; Eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa, isoform CRA_b; cDNA, FLJ93495, highly similar to Homo sapiens eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa (EIF2S2), mRNA Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0002176 [male germ cell proliferation] GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005850 [eukaryotic translation initiation factor 2 complex] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0008135 [translation factor activity, RNA binding] GO:0008584 [male gonad development] GO:0010467 [gene expression] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] Show all	333 aa 38.4 kDa	No	0