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GRPR

GENERAL INFORMATION

Gene name

 GRPR

Gene description

 Gastrin-releasing peptide receptor

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (breast cancer)
HPA (cell line):Group enriched (PC-3, T-47d, U-138 MG)
HPA (normal tissue):Tissue enhanced (pancreas)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (breast cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 GRPR (HGNC Symbol)

Synonyms

 BB2

Description

 Gastrin-releasing peptide receptor (HGNC Symbol)

Entrez gene summary

 Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 16123556 - 16153021

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126010 (version 83.38)

Entrez gene

 2925

UniProt

 P30550 (UniProt - Evidence at transcript level)

neXtProt

 NX_P30550

Antibodypedia

 GRPR antibodies

PROTEIN BROWSER
GRPR-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRPR-001
ENSP00000369643
ENST00000380289
P30550 [Direct mapping]
Gastrin-releasing peptide receptor
X5D7H2 [Target identity:100%; Query identity:100%]
Gastrin-releasing peptide receptor isoform A
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0004930 [G-protein coupled receptor activity]
GO:0004946 [bombesin receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008283 [cell proliferation]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0016021 [integral component of membrane]
GO:0031989 [bombesin receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
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 384 aa
43.2 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.