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AMOT

GENERAL INFORMATION

Gene name

 AMOT

Gene description

 Angiomotin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22)
HPA (normal tissue):Tissue enhanced (epididymis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in endothelium and placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
HPA067290
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA067290

GENE INFORMATION

Gene name

 AMOT (HGNC Symbol)

Synonyms

 KIAA1071

Description

 Angiomotin (HGNC Symbol)

Entrez gene summary

 This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q23

Chromosome location (bp)

 112774503 - 112840815

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126016 (version 83.38)

Entrez gene

 154796

UniProt

 Q4VCS5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q4VCS5

Antibodypedia

 AMOT antibodies

PROTEIN BROWSER
AMOT-001
AMOT-003
AMOT-004
AMOT-005
AMOT-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AMOT-001
ENSP00000305557
ENST00000304758
Q4VCS5 [Direct mapping]
Angiomotin
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005923 [bicellular tight junction]
GO:0007043 [cell-cell junction assembly]
GO:0008180 [COP9 signalosome]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0030139 [endocytic vesicle]
GO:0030334 [regulation of cell migration]
GO:0034613 [cellular protein localization]
GO:0035329 [hippo signaling]
GO:0043116 [negative regulation of vascular permeability]
GO:0043532 [angiostatin binding]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045793 [positive regulation of cell size]
GO:0051496 [positive regulation of stress fiber assembly]
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 675 aa
72.5 kDa 		No 0
AMOT-003
ENSP00000361026
ENST00000371958
A6NP16 [Direct mapping]
Angiomotin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 597 aa
68.4 kDa 		No 0
AMOT-004
ENSP00000361030
ENST00000371962
E7ERM3 [Direct mapping]
Angiomotin
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 852 aa
92.5 kDa 		No 0
AMOT-005
ENSP00000429013
ENST00000524145
Q4VCS5 [Direct mapping]
Angiomotin
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005923 [bicellular tight junction]
GO:0007043 [cell-cell junction assembly]
GO:0008180 [COP9 signalosome]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0030139 [endocytic vesicle]
GO:0030334 [regulation of cell migration]
GO:0034613 [cellular protein localization]
GO:0035329 [hippo signaling]
GO:0043116 [negative regulation of vascular permeability]
GO:0043532 [angiostatin binding]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045793 [positive regulation of cell size]
GO:0051496 [positive regulation of stress fiber assembly]
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 1084 aa
118.1 kDa 		No 0
AMOT-201
ENSP00000361027
ENST00000371959
Q4VCS5 [Direct mapping]
Angiomotin
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001570 [vasculogenesis]
GO:0001701 [in utero embryonic development]
GO:0001702 [gastrulation with mouth forming second]
GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0003365 [establishment of cell polarity involved in ameboidal cell migration]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005923 [bicellular tight junction]
GO:0006935 [chemotaxis]
GO:0007043 [cell-cell junction assembly]
GO:0008180 [COP9 signalosome]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0030139 [endocytic vesicle]
GO:0030334 [regulation of cell migration]
GO:0031410 [cytoplasmic vesicle]
GO:0034260 [negative regulation of GTPase activity]
GO:0034613 [cellular protein localization]
GO:0035329 [hippo signaling]
GO:0040019 [positive regulation of embryonic development]
GO:0042074 [cell migration involved in gastrulation]
GO:0043116 [negative regulation of vascular permeability]
GO:0043532 [angiostatin binding]
GO:0043534 [blood vessel endothelial cell migration]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045793 [positive regulation of cell size]
GO:0048514 [blood vessel morphogenesis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051496 [positive regulation of stress fiber assembly]
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 1084 aa
118.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.