Expression of UROD in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	UROD
Gene description	Uroporphyrinogen decarboxylase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues. Additional nuclear staininig in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA027468 , HPA028668
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA027468	HPA028668

GENE INFORMATION
Gene name	UROD
Synonyms
Description	Uroporphyrinogen decarboxylase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]
Chromosome	1
Cytoband	p34.1
Chromosome location (bp)	45012147 - 45015575
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126088 (version 83.38)
Entrez gene	7389
UniProt	P06132 (UniProt - Evidence at protein level)
neXtProt	NX_P06132
Antibodypedia	UROD antibodies

PROTEIN BROWSER

UROD-001	UROD-003	UROD-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UROD-001 ENSP00000246337 ENST00000246337	P06132 [Direct mapping] Uroporphyrinogen decarboxylase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0004853 [uroporphyrinogen decarboxylase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006778 [porphyrin-containing compound metabolic process] GO:0006779 [porphyrin-containing compound biosynthetic process] GO:0006782 [protoporphyrinogen IX biosynthetic process] GO:0006783 [heme biosynthetic process] GO:0008198 [ferrous iron binding] GO:0010039 [response to iron ion] GO:0014070 [response to organic cyclic compound] GO:0014075 [response to amine] GO:0032355 [response to estradiol] GO:0042168 [heme metabolic process] GO:0044281 [small molecule metabolic process] GO:0045471 [response to ethanol] GO:0046502 [uroporphyrinogen III metabolic process] GO:0046689 [response to mercury ion] GO:0051597 [response to methylmercury] GO:0060992 [response to fungicide] GO:0071243 [cellular response to arsenic-containing substance] Show all	367 aa 40.8 kDa	No	0
UROD-003 ENSP00000400253 ENST00000428106	H0Y5R6 [Direct mapping] Uroporphyrinogen decarboxylase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004853 [uroporphyrinogen decarboxylase activity] GO:0005829 [cytosol] GO:0006779 [porphyrin-containing compound biosynthetic process] GO:0006783 [heme biosynthetic process] Show all	228 aa 25.3 kDa	No	0
UROD-004 ENSP00000404489 ENST00000434478	Q5T446 [Direct mapping] Uroporphyrinogen decarboxylase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004853 [uroporphyrinogen decarboxylase activity] GO:0005829 [cytosol] GO:0006779 [porphyrin-containing compound biosynthetic process] GO:0006783 [heme biosynthetic process] Show all	193 aa 21.5 kDa	No	0