Expression of SLURP1 in cancer - Summary - The Human Protein Atlas

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SLURP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLURP1
Gene description	Secreted LY6/PLAUR domain containing 1
Protein class	Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enhanced (HaCaT, MCF7, T-47d)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in several squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA050967
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA050967

GENE INFORMATION
Gene name	SLURP1 (HGNC Symbol)
Synonyms	ANUP, ARS, ArsB, LY6LS, MDM
Description	Secreted LY6/PLAUR domain containing 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	142740944 - 142742411
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126233 (version 83.38)
Entrez gene	57152
UniProt	P55000 (UniProt - Evidence at protein level)
neXtProt	NX_P55000
Antibodypedia	SLURP1 antibodies

PROTEIN BROWSER

SLURP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLURP1-001 ENSP00000246515 ENST00000246515	P55000 [Direct mapping] Secreted Ly-6/uPAR-related protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001775 [cell activation] GO:0005125 [cytokine activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0007626 [locomotory behavior] GO:0010839 [negative regulation of keratinocyte proliferation] GO:0050884 [neuromuscular process controlling posture] GO:0070062 [extracellular exosome] Show all	103 aa 11.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.