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THRA

GENERAL INFORMATION

Gene name

 THRA

Gene description

 Thyroid hormone receptor, alpha

Protein class

 Cancer-related genes
Disease related genes
FDA approved drug targets
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA009654 , CAB023349
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA009654
CAB023349

GENE INFORMATION

Gene name

 THRA (HGNC Symbol)

Synonyms

 AR7, EAR-7.1/EAR-7.2, ERBA, ERBA1, NR1A1, THRA1, THRA2, THRA3

Description

 Thyroid hormone receptor, alpha (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.1

Chromosome location (bp)

 40058290 - 40093867

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126351 (version 83.38)

Entrez gene

 7067

UniProt

 P10827 (UniProt - Evidence at protein level)

neXtProt

 NX_P10827

Antibodypedia

 THRA antibodies

PROTEIN BROWSER
THRA-001
THRA-002
THRA-003
THRA-005
THRA-006
THRA-007
THRA-008
THRA-009
THRA-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
THRA-001
ENSP00000264637
ENST00000264637
P10827 [Direct mapping]
Thyroid hormone receptor alpha
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001502 [cartilage condensation]
GO:0001503 [ossification]
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0002153 [steroid receptor RNA activator RNA binding]
GO:0002155 [regulation of thyroid hormone mediated signaling pathway]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003727 [single-stranded RNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007420 [brain development]
GO:0007611 [learning or memory]
GO:0008016 [regulation of heart contraction]
GO:0008050 [female courtship behavior]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009409 [response to cold]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0010467 [gene expression]
GO:0010831 [positive regulation of myotube differentiation]
GO:0017025 [TBP-class protein binding]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019904 [protein domain specific binding]
GO:0030218 [erythrocyte differentiation]
GO:0030324 [lung development]
GO:0030325 [adrenal gland development]
GO:0030522 [intracellular receptor signaling pathway]
GO:0030878 [thyroid gland development]
GO:0031490 [chromatin DNA binding]
GO:0031667 [response to nutrient levels]
GO:0032403 [protein complex binding]
GO:0033032 [regulation of myeloid cell apoptotic process]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0042994 [cytoplasmic sequestering of transcription factor]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044213 [intronic transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045925 [positive regulation of female receptivity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048565 [digestive tract development]
GO:0048568 [embryonic organ development]
GO:0050994 [regulation of lipid catabolic process]
GO:0060509 [Type I pneumocyte differentiation]
GO:0070324 [thyroid hormone binding]
GO:2000143 [negative regulation of DNA-templated transcription, initiation]
Show all
 490 aa
54.8 kDa 		No 0
THRA-002
ENSP00000395641
ENST00000450525
P10827 [Direct mapping]
Thyroid hormone receptor alpha
Q6FH41 [Target identity:100%; Query identity:100%]
THRA protein; Thyroid hormone receptor, alpha (Erythroblastic leukemia viral (V-erb-a) oncogene homolog, avian), isoform CRA_b; Thyroid normone nuclear receptor alpha variant 1
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009755 [hormone-mediated signaling pathway]
GO:0010467 [gene expression]
GO:0017025 [TBP-class protein binding]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019904 [protein domain specific binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070324 [thyroid hormone binding]
GO:2000143 [negative regulation of DNA-templated transcription, initiation]
Show all
 410 aa
46.8 kDa 		No 0
THRA-003
ENSP00000377679
ENST00000394121
P10827 [Direct mapping]
Thyroid hormone receptor alpha
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009755 [hormone-mediated signaling pathway]
GO:0010467 [gene expression]
GO:0017025 [TBP-class protein binding]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019904 [protein domain specific binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070324 [thyroid hormone binding]
GO:2000143 [negative regulation of DNA-templated transcription, initiation]
Show all
 490 aa
54.8 kDa 		No 0
THRA-005
ENSP00000463466
ENST00000584985
P10827 [Direct mapping]
Thyroid hormone receptor alpha
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009755 [hormone-mediated signaling pathway]
GO:0010467 [gene expression]
GO:0017025 [TBP-class protein binding]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019904 [protein domain specific binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070324 [thyroid hormone binding]
GO:2000143 [negative regulation of DNA-templated transcription, initiation]
Show all
 451 aa
50.7 kDa 		No 0
THRA-006
ENSP00000443972
ENST00000546243
P10827 [Direct mapping]
Thyroid hormone receptor alpha
Q6FH41 [Target identity:100%; Query identity:100%]
THRA protein; Thyroid hormone receptor, alpha (Erythroblastic leukemia viral (V-erb-a) oncogene homolog, avian), isoform CRA_b; Thyroid normone nuclear receptor alpha variant 1
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009755 [hormone-mediated signaling pathway]
GO:0010467 [gene expression]
GO:0017025 [TBP-class protein binding]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019904 [protein domain specific binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070324 [thyroid hormone binding]
GO:2000143 [negative regulation of DNA-templated transcription, initiation]
Show all
 410 aa
46.8 kDa 		No 0
THRA-007
ENSP00000464013
ENST00000577288
J3QR26 [Direct mapping]
Thyroid hormone receptor alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 31 aa
3.4 kDa 		No 0
THRA-008
ENSP00000462955
ENST00000585047
J3KTF3 [Direct mapping]
Thyroid hormone receptor alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043565 [sequence-specific DNA binding]
Show all
 72 aa
8 kDa 		No 0
THRA-009
ENSP00000464123
ENST00000578218
J3QRA9 [Direct mapping]
Thyroid hormone receptor alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004887 [thyroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 85 aa
9.6 kDa 		No 0
THRA-010
ENSP00000464414
ENST00000577486
J3QRW5 [Direct mapping]
Thyroid hormone receptor alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 57 aa
6.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.