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NR1D1

GENERAL INFORMATION

Gene name

 NR1D1

Gene description

 Nuclear receptor subfamily 1, group D, member 1

Protein class

 Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA007935
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (favourable) and colorectal cancer (unfavourable).
Melanoma p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007935

GENE INFORMATION

Gene name

 NR1D1 (HGNC Symbol)

Synonyms

 ear-1, hRev, Rev-ErbAalpha, THRA1, THRAL

Description

 Nuclear receptor subfamily 1, group D, member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]

Chromosome

 17

Cytoband

 q21.1

Chromosome location (bp)

 40092787 - 40100725

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126368 (version 83.38)

Entrez gene

 9572

UniProt

 P20393 (UniProt - Evidence at protein level)

neXtProt

 NX_P20393

Antibodypedia

 NR1D1 antibodies

PROTEIN BROWSER
NR1D1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR1D1-001
ENSP00000246672
ENST00000246672
P20393 [Direct mapping]
Nuclear receptor subfamily 1 group D member 1
F1D8S3 [Target identity:100%; Query identity:100%]
Nuclear receptor Rev-ErbA-alpha; Nuclear receptor subfamily 1, group D, member 1
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Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001222 [transcription corepressor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005978 [glycogen biosynthetic process]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010498 [proteasomal protein catabolic process]
GO:0010871 [negative regulation of receptor biosynthetic process]
GO:0019216 [regulation of lipid metabolic process]
GO:0020037 [heme binding]
GO:0030154 [cell differentiation]
GO:0030425 [dendrite]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032922 [circadian regulation of gene expression]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0035947 [regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter]
GO:0042752 [regulation of circadian rhythm]
GO:0043197 [dendritic spine]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044321 [response to leptin]
GO:0045598 [regulation of fat cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060086 [circadian temperature homeostasis]
GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0061469 [regulation of type B pancreatic cell proliferation]
GO:0070859 [positive regulation of bile acid biosynthetic process]
GO:0071222 [cellular response to lipopolysaccharide]
GO:2000188 [regulation of cholesterol homeostasis]
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 614 aa
66.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.