Expression of BCL2L12 in cancer - Summary - The Human Protein Atlas

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BCL2L12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BCL2L12
Gene description	BCL2-like 12 (proline rich)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA020856
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020856

GENE INFORMATION
Gene name	BCL2L12
Synonyms
Description	BCL2-like 12 (proline rich) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49665142 - 49673916
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126453 (version 83.38)
Entrez gene	83596
UniProt	Q9HB09 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HB09
Antibodypedia	BCL2L12 antibodies

PROTEIN BROWSER

BCL2L12-001	BCL2L12-002	BCL2L12-004	BCL2L12-006	BCL2L12-008	BCL2L12-009	BCL2L12-201	BCL2L12-202	BCL2L12-203	BCL2L12-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCL2L12-001 ENSP00000246785 ENST00000246785	Q9HB09 [Direct mapping] Bcl-2-like protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016020 [membrane] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] Show all	334 aa 36.8 kDa	No	0
BCL2L12-002 ENSP00000393803 ENST00000441864	Q9HB09 [Direct mapping] Bcl-2-like protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016020 [membrane] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] Show all	333 aa 36.7 kDa	No	0
BCL2L12-004 ENSP00000469216 ENST00000594157	M0R1K0 [Direct mapping] Bcl-2-like protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 9.2 kDa	No	0
BCL2L12-006 ENSP00000470644 ENST00000600947	M0QZM6 [Direct mapping] Bcl-2-like protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		138 aa 14.7 kDa	No	0
BCL2L12-008 ENSP00000472214 ENST00000598306	M0R1Z8 [Direct mapping] Bcl-2-like protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 10 kDa	No	0
BCL2L12-009 ENSP00000246784 ENST00000246784	A0A087WSV0 [Direct mapping] Bcl-2-like protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		250 aa 26.9 kDa	No	0
BCL2L12-201 ENSP00000478415 ENST00000611631	I6LK00 [Direct mapping] BCL2L12 protein isoform 9; Bcl-2-like protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 15 kDa	No	0
BCL2L12-202 ENSP00000482154 ENST00000614495	I6LJZ9 [Direct mapping] BCL2L12 protein isoform 8; Bcl-2-like protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		193 aa 21.4 kDa	No	0
BCL2L12-203 ENSP00000482218 ENST00000616144	Q9HB09 [Direct mapping] Bcl-2-like protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002039 [p53 binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016020 [membrane] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] GO:2000773 [negative regulation of cellular senescence] Show all	334 aa 36.8 kDa	No	0
BCL2L12-204 ENSP00000483272 ENST00000619007	I6LJZ7 [Direct mapping] BCL2L12 protein isoform 5; Bcl-2-like protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		269 aa 29.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.