We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Signal transducer and activator of transcription 5A (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
P42229 [Direct mapping] Signal transducer and activator of transcription 5A
Show all
Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000255 [allantoin metabolic process] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001553 [luteinization] GO:0001779 [natural killer cell differentiation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006101 [citrate metabolic process] GO:0006103 [2-oxoglutarate metabolic process] GO:0006105 [succinate metabolic process] GO:0006107 [oxaloacetate metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006549 [isoleucine metabolic process] GO:0006573 [valine metabolic process] GO:0006600 [creatine metabolic process] GO:0006631 [fatty acid metabolic process] GO:0007165 [signal transduction] GO:0007259 [JAK-STAT cascade] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0008284 [positive regulation of cell proliferation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019218 [regulation of steroid metabolic process] GO:0019221 [cytokine-mediated signaling pathway] GO:0019530 [taurine metabolic process] GO:0019915 [lipid storage] GO:0030155 [regulation of cell adhesion] GO:0030856 [regulation of epithelial cell differentiation] GO:0030879 [mammary gland development] GO:0032825 [positive regulation of natural killer cell differentiation] GO:0033026 [negative regulation of mast cell apoptotic process] GO:0033077 [T cell differentiation in thymus] GO:0038161 [prolactin signaling pathway] GO:0040014 [regulation of multicellular organism growth] GO:0040018 [positive regulation of multicellular organism growth] GO:0042104 [positive regulation of activated T cell proliferation] GO:0043029 [T cell homeostasis] GO:0043066 [negative regulation of apoptotic process] GO:0043434 [response to peptide hormone] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045588 [positive regulation of gamma-delta T cell differentiation] GO:0045621 [positive regulation of lymphocyte differentiation] GO:0045647 [negative regulation of erythrocyte differentiation] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0046449 [creatinine metabolic process] GO:0046543 [development of secondary female sexual characteristics] GO:0046544 [development of secondary male sexual characteristics] GO:0048541 [Peyer's patch development] GO:0050729 [positive regulation of inflammatory response] GO:0060376 [positive regulation of mast cell differentiation] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0060740 [prostate gland epithelium morphogenesis] GO:0060742 [epithelial cell differentiation involved in prostate gland development] GO:0061180 [mammary gland epithelium development] GO:0070668 [positive regulation of mast cell proliferation] GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
P42229 [Direct mapping] Signal transducer and activator of transcription 5A
Show all
Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
P42229 [Direct mapping] Signal transducer and activator of transcription 5A
Show all
Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)