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This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000045 [autophagosome assembly] GO:0000407 [pre-autophagosomal structure] GO:0000910 [cytokinesis] GO:0001666 [response to hypoxia] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005768 [endosome] GO:0005776 [autophagosome] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0006914 [autophagy] GO:0006968 [cellular defense response] GO:0006995 [cellular response to nitrogen starvation] GO:0007040 [lysosome organization] GO:0007080 [mitotic metaphase plate congression] GO:0008285 [negative regulation of cell proliferation] GO:0010008 [endosome membrane] GO:0010508 [positive regulation of autophagy] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016032 [viral process] GO:0016236 [macroautophagy] GO:0016239 [positive regulation of macroautophagy] GO:0019898 [extrinsic component of membrane] GO:0030425 [dendrite] GO:0031625 [ubiquitin protein ligase binding] GO:0031966 [mitochondrial membrane] GO:0032258 [CVT pathway] GO:0032465 [regulation of cytokinesis] GO:0032801 [receptor catabolic process] GO:0033197 [response to vitamin E] GO:0034271 [phosphatidylinositol 3-kinase complex, class III, type I] GO:0034272 [phosphatidylinositol 3-kinase complex, class III, type II] GO:0035032 [phosphatidylinositol 3-kinase complex, class III] GO:0042149 [cellular response to glucose starvation] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043652 [engulfment of apoptotic cell] GO:0044804 [nucleophagy] GO:0045324 [late endosome to vacuole transport] GO:0045335 [phagocytic vesicle] GO:0048666 [neuron development] GO:0050435 [beta-amyloid metabolic process] GO:0050790 [regulation of catalytic activity] GO:0051607 [defense response to virus] GO:0051707 [response to other organism] GO:0060548 [negative regulation of cell death] GO:0071275 [cellular response to aluminum ion] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0098779 [mitophagy in response to mitochondrial depolarization] GO:1902425 [positive regulation of attachment of mitotic spindle microtubules to kinetochore] GO:1903599 [positive regulation of mitophagy] GO:2000378 [negative regulation of reactive oxygen species metabolic process]