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RNA cell line category: Cell line enhanced (A549, SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
PRKCG (HGNC Symbol)
Synonyms
MGC57564, PKCC, PKCG, SCA14
Description
Protein kinase C, gamma (HGNC Symbol)
Entrez gene summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
P05129 [Direct mapping] Protein kinase C gamma type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0004698 [calcium-dependent protein kinase C activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0007611 [learning or memory] GO:0007635 [chemosensory behavior] GO:0008270 [zinc ion binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016310 [phosphorylation] GO:0030168 [platelet activation] GO:0030425 [dendrite] GO:0031397 [negative regulation of protein ubiquitination] GO:0032095 [regulation of response to food] GO:0032425 [positive regulation of mismatch repair] GO:0035556 [intracellular signal transduction] GO:0042177 [negative regulation of protein catabolic process] GO:0042752 [regulation of circadian rhythm] GO:0043005 [neuron projection] GO:0043278 [response to morphine] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045087 [innate immune response] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048265 [response to pain] GO:0048471 [perinuclear region of cytoplasm] GO:0048511 [rhythmic process] GO:0050764 [regulation of phagocytosis] GO:0060384 [innervation] GO:0097060 [synaptic membrane] GO:0097481 [neuronal postsynaptic density] GO:1901799 [negative regulation of proteasomal protein catabolic process]
