Expression of DNAJC8 in cancer - Summary - The Human Protein Atlas

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DNAJC8

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DNAJC8
Gene description	DnaJ (Hsp40) homolog, subfamily C, member 8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA026283
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), thyroid cancer (favourable) and liver cancer (unfavourable).
Endometrial cancer p<0.001 Thyroid cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026283

GENE INFORMATION
Gene name	DNAJC8 (HGNC Symbol)
Synonyms	SPF31
Description	DnaJ (Hsp40) homolog, subfamily C, member 8 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p35.3
Chromosome location (bp)	28199456 - 28233025
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126698 (version 83.38)
Entrez gene	22826
UniProt	O75937 (UniProt - Evidence at protein level)
neXtProt	NX_O75937
Antibodypedia	DNAJC8 antibodies

PROTEIN BROWSER

DNAJC8-001	DNAJC8-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAJC8-001 ENSP00000263697 ENST00000263697	O75937 [Direct mapping] DnaJ homolog subfamily C member 8 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005654 [nucleoplasm] GO:0008380 [RNA splicing] GO:0010467 [gene expression] Show all	253 aa 29.8 kDa	No	0
DNAJC8-006 ENSP00000474440 ENST00000603289	S4R3J5 [Direct mapping] DnaJ homolog subfamily C member 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 13 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.