Expression of DACH2 in cancer - Summary - The Human Protein Atlas

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DACH2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DACH2
Gene description	Dachshund family transcription factor 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (cerebral cortex, epididymis, fallopian tube)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Nuclear expression in CNS and fallopian tube.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 1 antibody. HPA000258
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000258

GENE INFORMATION
Gene name	DACH2
Synonyms
Description	Dachshund family transcription factor 2 (HGNC Symbol)
Entrez gene summary	This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Chromosome	X
Cytoband	q21.2
Chromosome location (bp)	86148458 - 86832604
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000126733 (version 83.38)
Entrez gene	117154
UniProt	Q96NX9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96NX9
Antibodypedia	DACH2 antibodies

PROTEIN BROWSER

DACH2-001	DACH2-002	DACH2-004	DACH2-006	DACH2-007	DACH2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DACH2-001 ENSP00000362223 ENST00000373131	Q96NX9 [Direct mapping] Dachshund homolog 2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	571 aa 61.9 kDa	No	0
DACH2-002 ENSP00000421919 ENST00000510272	Q96NX9 [Direct mapping] Dachshund homolog 2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	380 aa 41.8 kDa	No	0
DACH2-004 ENSP00000422727 ENST00000484479	H0Y912 [Direct mapping] Dachshund homolog 2 Show all	Predicted intracellular proteins Show all		249 aa 27.8 kDa	No	0
DACH2-006 ENSP00000420896 ENST00000508860	Q96NX9 [Direct mapping] Dachshund homolog 2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	432 aa 47.2 kDa	No	0
DACH2-007 ENSP00000362217 ENST00000373125	Q96NX9 [Direct mapping] Dachshund homolog 2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046545 [development of primary female sexual characteristics] Show all	599 aa 65.3 kDa	No	0
DACH2-201 ENSP00000478116 ENST00000613770	A0A087WTT5 [Direct mapping] Dachshund homolog 2 Show all	Predicted intracellular proteins Show all		427 aa 46.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.