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EMG1

GENERAL INFORMATION

Gene name

 EMG1

Gene description

 EMG1 N1-specific pseudouridine methyltransferase

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nucleolar expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA039666
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Oral mucosa

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 EMG1 (HGNC Symbol)

Synonyms

 C2F, Grcc2f, NEP1

Description

 EMG1 N1-specific pseudouridine methyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes an essential, conserved eukaryotic protein involved in ribosome biogenesis. In yeast, the related protein is a component of the small subunit processome and is essential for biogenesis of the ribosomal 40S subunit. A mutation in this gene has been associated with Bowen-Conradi syndrome.[provided by RefSeq, May 2010]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6970893 - 6979941

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126749 (version 83.38)

Entrez gene

 10436

UniProt

 Q92979 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92979

Antibodypedia

 EMG1 antibodies

PROTEIN BROWSER
EMG1-001
EMG1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EMG1-001
ENSP00000470560
ENST00000599672
Q92979 [Direct mapping]
Ribosomal RNA small subunit methyltransferase NEP1
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0008168 [methyltransferase activity]
GO:0019843 [rRNA binding]
GO:0031167 [rRNA methylation]
GO:0042274 [ribosomal small subunit biogenesis]
GO:0044822 [poly(A) RNA binding]
GO:0070037 [rRNA (pseudouridine) methyltransferase activity]
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 244 aa
26.7 kDa 		No 0
EMG1-005
ENSP00000479546
ENST00000539196
A0A087WVM7 [Direct mapping]
Ribosomal RNA small subunit methyltransferase NEP1
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Predicted intracellular proteins
Show all
GO:0008168 [methyltransferase activity]
GO:0032259 [methylation]
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 149 aa
16.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.